Epidemiologiske forhold ved ankyloserende spondylitt
DOI:
https://doi.org/10.5324/nje.v18i1.56Sammendrag
Ankyloserende spondylitt er en inflammatorisk revmatisk sykdom som hovedsakelig affiserer ileosakralledd og kolumna, og den er assosiert til perifere artritter, inflammatorisk tarmsykdom, psoriasis og Reiters syndrom. Forekomsten er korrelert til utbredelsen av HLA B27, og viser derved en viss geografisk variasjon. I europeiske studier finner man en generell prevalens av AS på 0,15-0,5%, men dette kan være høyere i enkelte subpopulasjoner med 1,8% rapportert i en norsk samisk populasjon. En norsk studie har indikert en insidens på ca. 1 per 10.000 personår i voksen befolkning, mens data fra Finland og USA viser noe lavere anslag. Det foreligger data som indikerer en økning av mortalitet på 50%, mens man i andre populasjoner ikke har funnet noen mortalitetsøkning. Nye og effektive behandlingsmuligheter stiller høye krav til tidlig diagnostikk, og utvikling samt validering av nye diagnostiske kriterier er en viktig utfordring.
Ankylosing spondylitis (AS) is an inflammatory rheumatic disease affecting the sacroiliac joints and spine. The prevalence of AS is correlated to that of HLA B27, which demonstrate a geographical gradient with higher occurrence in the northern circumpolar areas. European populations studies indicate a prevalence of
0.15-0.5%, although it could be as high as 1.8% in some subpopulations. There are few studies concerning the incidence rate of AS, but a Norwegian study indicates an annual incidence of 1 per 10.000 in the adult population. There are contradicting studies regarding mortality. Some indicate that it may be increased by
50%, whereas others show no increased mortality
Downloads
Nedlastinger
Publisert
Hvordan referere
Utgave
Seksjon
Lisens
Norsk Epidemiologi licenses all content of the journal under a Creative Commons Attribution (CC-BY) licence. This means, among other things, that anyone is free to copy and distribute the content, as long as they give proper credit to the author(s) and the journal. For further information, see Creative Commons website for human readable or lawyer readable versions.
Authors who publish with this journal agree to the following terms:
1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
