Medfødte misdannelser og fars yrkeseksposisjon
DOI:
https://doi.org/10.5324/nje.v7i1.348Sammendrag
SAMMENDRAG
Hypoteser basert på funn fra tidligere studier av misdannelser hos barn av fedre i ulike yrkesgrupper (1), ble
etterprøvet i et norsk registermateriale. Materialet besto av data fra Medisinsk fødselsregister (MFR) 1970-93,
koblet med data fra Folke- og boligtellinger (FOB) fra 1970, 1980 og 1990 med opplysninger om bl.a. fars
yrke. Som referansepopulasjon ble benyttet barn av fedre med alle andre yrker enn det som ble analysert.
Barn av malere hadde tendens til økt risiko for spina bifida – OR 2,03 (CI 0,99–3,75) og barn av trykkeriarbeidere
hadde økt risiko for klumpfot – OR 1,52 (CI 1,10–2,10). Studien har bidradd til å sannsynliggjøre
en kausal sammenheng knyttet til påviste samvariasjoner, dog uten å belyse mekanismer. Tidligere positive
funn hos barn av fedre i enkelte store yrkesgrupper som lærere, elektriske yrker, salgsrelaterte yrker, bønder
og sjåfører ble ikke bekreftet i vårt materiale. Eventuelt falske negative funn kan skyldes lav statistisk styrke
på grunn av små grupper eller problemer med ikke differensiell feilklassifisering av eksposisjon.
Irgens Å, Krüger K, Skorve AH, Irgens LM.
Birth defects and paternal occupational exposure.
Hypotheses derived from previous studies tested in a Norwegian registry material.
Nor J Epidemiol
Aim
Method
Results
Conclusion
. The study gave evidence of cause effect relationships in the confirmed positive associations,
though without any clarification of possible mechanisms involved. Possible false negative findings might be
due to low statistical power as a result of small occupational groups or non differential problems of misclassification
of exposure.
. Offspring of painters had a tendency of increased risk of spina bifida – OR 2,03 (CI 0,99–3,75) andoffspring of printers had an increased risk for talipes – OR 1,52 (CI 1,10–2,10). Positive associations
observed previously in offspring of fathers in large occupational groups such as teachers, drivers, electricity
related occupations, sales related occupations and agricultural workers were not confirmed in this dataset.
. The study was based on all births in Norway 1970–1993 for which linkage with population censuses1970, 1980 and 1990 could be obtained – about 1 million births. The reference population was offspring of
the group that did not belong to the actual occupation.
ENGLISH SUMMARY. To test, on the basis of a Norwegian registry material, previously established hypotheses on associations
of birth defects with paternal occupation (1).
1997; 7 (1): 13-18.Downloads
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