Heterofile antistoffer - en kilde til analyseinterferens
DOI:
https://doi.org/10.5324/nje.v16i1.202Sammendrag
Sirkulerende naturlig forekommende humane antistoffer mot humane antistoffer (rheumatoide faktorer) og mot dyreantistoffer (heterofile antistoffer) har evner til å binde analyseantistoffer som brukes i en immunometrisk analyse. Resultatet er oftest et falsk forhøyet prøvesvar (positiv interferens) og noen ganger et falsk for lavt svar (negativ interferens). Slik interferens kan reduseres betydelig gjennom modifisering av analyseantistoffene og gjennom buffertilsetninger, men forekomsten av interferens kan i dag ikke helt elimineres. Det er derfor viktig at klinikeren kjenner til risikoen for interferens, og gir laboratoriet tilbakemelding dersom prøvesvaret ikke stemmer med klinikken
Heterophilic antibodies – a source of analytical interference. Human antibodies binding human or animal antibodies may cause aberrant results in immunometric assays by binding the assay antibodies involved. The result may be falsely elevated (positive interference) or falsely low (negative interference). Both the frequency and the size of the aberrations may be reduced by either modifying the assay antibodies or by using buffer additives. However, as such interference cannot be completely eradicated, awareness of physicans and scientists is strongly needed.
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