Individuell variasjon i utskillelse av 6-sulfatoksymelatonin og døgnrytmetype analysert hos skiftarbeidere
DOI:
https://doi.org/10.5324/nje.v9i1.440Abstract
SAMMENDRAG
I denne studien har vi undersøkt om det finnes noen sammenheng mellom målte verdier av urinmetabolitten
6-sulfatoxymelatonin (aMT6s) tatt ut i porsjoner gjennom døgnet og selvrapportert døgnrytme hos en
gruppe norske skiftarbeidere. Studien omfatter 19 arbeidstakere ved to produksjonsenheter ved Hydro
Porsgrunn, magnesiumfabrikken og fullgjødselfabrikk 3. Etter å ha deltatt i en studie der urinprøver ble
samlet inn, svarte de involverte senere på et spørreskjema om søvn og døgnrytme. Resultatene indikerer at
egenrapporterte B-type mennesker har en tendens til høyere midlere timeutskillelse av aMT6s analysert på
døgnbasis første døgn med nattskift, og en signifikant høyere nattutskillelse (8 timer) i et kontrolldøgn
hjemme. I fremtidige studier av melatoninsekresjon og utskillelse av metabolitt i urin, kan det være av
interesse samtidig å samle inn spørreskjemabaserte opplysninger om døgnrytmetype og utfyllende opplysninger
om søvn og søvnmønster i relasjon til eksponeringer som skiftarbeid og andre arbeidsmiljøfaktorer
som kan ha effekt på hormonbalansen.
Tynes T, Haugsdal B, Tønnessen A, Kleiven M.
Individual variations in excretion of
6-sulfatoxymelatonin in morning and evening type Norwegian shift workers.
Nor J Epidemiol
ENGLISH SUMMARY
The aim of this study was to evaluate whether there is an association between measured values of the urine
metabolite 6-sulfatoxymelatonin (aMT6s) in samples collected at selected intervals and self-reported diurnal
rhythm in a group of Norwegian shift workers. The study included 19 workers at two production units
at Hydro Porsgrunn, the magnesium factory and fertiliser factory 3. After submitting the urine samples
used for the study, subjects filled in a questionnaire on sleep and diurnal rhythm at a later date. The results
indicate that self-reported evening type subjects have a tendency towards a higher mean hourly aMT6ssecretion
first day on night shift, and a significantly higher night secretion (8 hours) analysed for a control
day at home. In future studies on secretion of melatonin and its metabolite in urine, the collection of
questionnaire-based information on diurnal type, sleep and sleep pattern in relation to exposures like shift
work, and other work-related factors with potential effect on hormone balance might be of interest.
1999; 9 (1): 33-38.Downloads
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