systems medicine – AFE-bloggen

Henrik Vogt ved AFE Trondheim er nylig intervjuet i New York Times med utgangspunkt i sitt doktorgradsarbeid. Han disputerte i 2017 med avhandlingen «Systems medicine as a theoretical framework for primary care medicine. A critical analysis» her på NTNU. I intervjuet sammenligner han den nye omics-preventive medisinen som «teppebombing» av kroppen.

Her er et utdrag fra intervjuet i NYT 8.mai 2019: «In This Doctor’s Office, a Physical Exam Like No Other»:

“They carpet-bomb the body with tests and basically assume that the discovery of everything they hit is beneficial,” said Dr. Henrik Vogt, a postdoctoral researcher at the University of Oslo. “But there may be lots of collateral damage they don’t consider.”

Dr. Vogt, an outspoken critic of precision medicine, also noted Dr. Snyder and his colleagues did not compare the outcomes of their volunteers to people who were getting standard medical care. The extra cost and effort might not have led to comparatively better health.

“It’s hard to know what the results mean,” Dr. Vogt said.

Henrik Vogt har fått på trykk en kommentar-artikkel i Nature Biotechnology, med tittelen: Precision medicine in the cloudes som handler om en kritikk av P100-studien, den første P4-studien (Hood et al).

To the Editor: A billion-dollar question is whether precision medicine (also known as personalized, ‘P4’ or systems medicine) can substantially increase the utility of individualized disease, prevention and population health. In this respect, the first results from the Pioneer 100 Wellness Project (P100), featured in last August’s issue, is a landmark. The study sheds light on an approach that has primarily existed as a vision and precedes the US National Institutes of Health’s (NIH; Bethesda, MD) All of Us study, which will include a million participants in a similar scheme (http://www.allofus.nih.gov/).