Marie Klevjer
Om
Forskning
Min forskning forsøker å forbedre risikoprediksjonen for hjerte- og karsykdom ved å utforske genetiske faktorer. Hovedfokuset er på treningsrelaterte risikofaktorer, hovedsakelig maksimalt oksygenopptak og hvilepuls. Prosjektet benytter seg av de nyeste metodene innen genetikk.
Publikasjoner
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study
In contrast with the current observational knowledge of RHR and AF, an inverse causal association between RHR and AF was demonstrated in both linear and non-linear MR for RHR values up to 90 bpm.
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study
We identified 38 novel SNP associated with V̇O 2peak in HUNT. Two SNP were nominally replicated in UKB. Several interesting genes emerged from the functional analyses, among them one previously reported to be associated with CVD and another with CRF.
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease
Our findings provide insight into the pleiotropic effects of the RHR variants, contributing towards an improved understanding of mechanisms linking RHR and disease.
2024
-
Joensuu, Laura;
Koivunen, Kaisa;
Tynkkynen, Niko Paavo;
Palviainen, Teemu;
Kaprio, Jaakko;
Klevjer, Marie.
(2024)
Genetic liability to sedentary behavior increases the risk of cardiovascular disease incidence: Evidence from the FinnGen cohort with 293,250 individuals.
medRxiv
Vitenskapelig artikkel
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Øvretveit, Karsten;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2024)
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.
European Journal of Preventive Cardiology (EJPC)
Vitenskapelig artikkel
2023
-
Tynkkynen, Niko Paavo;
Törmäkangas, Timo;
Palviainen, Teemu;
Hyvärinen, Matti;
Klevjer, Marie;
Joensuu, Laura.
(2023)
Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study.
European Journal of Epidemiology (EJE)
Vitenskapelig artikkel
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Wisløff, Ulrik;
Langaas, Mette;
Bye, Anja.
(2023)
Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study.
Physiological Genomics
Vitenskapelig artikkel
-
Sperstad, Sigri Bakken;
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Røsbjørgen, Ragnhild.
(2023)
Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study.
PLOS ONE
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Vitenskapelig oversiktsartikkel/review
-
Klevjer, Marie;
Rasheed, Humaira;
Romundstad, Pål Richard;
Madssen, Erik;
Brumpton, Ben Michael;
Bye, Anja.
(2023)
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study.
Europace
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory
fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Vitenskapelig oversiktsartikkel/review
2022
-
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Gigante, Bruna;
Gjære, Sigrid.
(2022)
Small LDL subfractions are associated with coronary atherosclerosis despite nodifferences in conventional lipids.
Physiological Genomics
Vitenskapelig artikkel
-
Nodeland, Markus;
Klevjer, Marie;
Sæther, Julie Caroline;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Wisløff, Ulrik.
(2022)
Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study.
Atherosclerosis
Vitenskapelig artikkel
-
Benegiamo, Giorgia;
Bou Sleiman, Maroun;
Wohlwend, Martin;
Rodríguez-López, Sandra;
Goeminne, Ludger J. E.;
Laurila, Pirkka-Pekka.
(2022)
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Nature Metabolism
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Hansen, Ailin Falkmo;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2022)
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study.
Medicine & Science in Sports & Exercise
Vitenskapelig artikkel
2020
-
Bye, Anja;
Klevjer, Marie;
Ryeng, Einar;
Silva, Gustavo Jose Justo;
Moreira, Jose Bianco Nascimento;
Stensvold, Dorthe.
(2020)
Identification of novel genetic variants associated with cardiorespiratory fitness.
Progress in cardiovascular diseases
Vitenskapelig oversiktsartikkel/review
2019
-
De Soysa, Ann Kristin Hjelle;
Klevjer, Marie;
Grill, Valdemar Erik Robert;
Mostad, Ingrid Løvold.
(2019)
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3.
Metabolism: Clinical and Experimental
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Joensuu, Laura;
Koivunen, Kaisa;
Tynkkynen, Niko Paavo;
Palviainen, Teemu;
Kaprio, Jaakko;
Klevjer, Marie.
(2024)
Genetic liability to sedentary behavior increases the risk of cardiovascular disease incidence: Evidence from the FinnGen cohort with 293,250 individuals.
medRxiv
Vitenskapelig artikkel
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Øvretveit, Karsten;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2024)
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.
European Journal of Preventive Cardiology (EJPC)
Vitenskapelig artikkel
-
Tynkkynen, Niko Paavo;
Törmäkangas, Timo;
Palviainen, Teemu;
Hyvärinen, Matti;
Klevjer, Marie;
Joensuu, Laura.
(2023)
Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study.
European Journal of Epidemiology (EJE)
Vitenskapelig artikkel
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Wisløff, Ulrik;
Langaas, Mette;
Bye, Anja.
(2023)
Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study.
Physiological Genomics
Vitenskapelig artikkel
-
Sperstad, Sigri Bakken;
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Røsbjørgen, Ragnhild.
(2023)
Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study.
PLOS ONE
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Vitenskapelig oversiktsartikkel/review
-
Klevjer, Marie;
Rasheed, Humaira;
Romundstad, Pål Richard;
Madssen, Erik;
Brumpton, Ben Michael;
Bye, Anja.
(2023)
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study.
Europace
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory
fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Vitenskapelig oversiktsartikkel/review
-
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Gigante, Bruna;
Gjære, Sigrid.
(2022)
Small LDL subfractions are associated with coronary atherosclerosis despite nodifferences in conventional lipids.
Physiological Genomics
Vitenskapelig artikkel
-
Nodeland, Markus;
Klevjer, Marie;
Sæther, Julie Caroline;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Wisløff, Ulrik.
(2022)
Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study.
Atherosclerosis
Vitenskapelig artikkel
-
Benegiamo, Giorgia;
Bou Sleiman, Maroun;
Wohlwend, Martin;
Rodríguez-López, Sandra;
Goeminne, Ludger J. E.;
Laurila, Pirkka-Pekka.
(2022)
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Nature Metabolism
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Hansen, Ailin Falkmo;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2022)
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study.
Medicine & Science in Sports & Exercise
Vitenskapelig artikkel
-
Bye, Anja;
Klevjer, Marie;
Ryeng, Einar;
Silva, Gustavo Jose Justo;
Moreira, Jose Bianco Nascimento;
Stensvold, Dorthe.
(2020)
Identification of novel genetic variants associated with cardiorespiratory fitness.
Progress in cardiovascular diseases
Vitenskapelig oversiktsartikkel/review
-
De Soysa, Ann Kristin Hjelle;
Klevjer, Marie;
Grill, Valdemar Erik Robert;
Mostad, Ingrid Løvold.
(2019)
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3.
Metabolism: Clinical and Experimental
Vitenskapelig artikkel
Formidling
2024
-
PosterKlevjer, Marie; Øvretveit, Karsten; Brumpton, Ben Michael; Wisløff, Ulrik; Hveem, Kristian; Bye, Anja. (2024) Polygenic prediction of cardiorespiratory fitness: The HUNT Study. Nordic Society of Human Genetics and Precision Medicine og Biobank Norway Nordic Conference on Future Health , Trondheim 2024-09-09 - 2024-09-12
2023
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PosterSæther, Julie Caroline; Follestad, Turid; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Bruna. (2023) Circulating lipoprotein subfractions and microRNAs as potential biomarkers for improved risk prediction of myocardial infarction: the HUNT study. Norwegian University of Science and Technology 3rd Nordic Metabolomics Conference , Trondheim 2023-10-18 - 2023-10-20
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PosterNordeidet, Ada Nilsen; Bye, Anja; Klevjer, Marie; Brumpton, Ben Michael; Wisløff, Ulrik; Madssen, Erik. (2023) Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease. NTNU Health A HEALTHY FUTURE , Trondheim 2023-10-05 -
2022
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PosterNordeidet, Ada Nilsen; Bye, Anja; Klevjer, Marie; Langaas, Mette. (2022) Cardiovascular disease-wide association study to investigate shared genetics with peak oxygen uptake. European Society of Cardiology ESC Congress 2022 , Barcelona 2022-08-26 - 2022-08-29
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Vitenskapelig foredragKlevjer, Marie; Nordeidet, Ada Nilsen; Hansen, Ailin Falkmo; Madssen, Erik; Wisløff, Ulrik; Brumpton, Ben Michael. (2022) Genome-wide association study identify new genetic determinants of cardiorespiratory fitness: The HUNT Study . ESC Preventive Cardiology 2022 2022-04-07 - 2022-04-09
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Vitenskapelig foredragKlevjer, Marie; Nordeidet, Ada Nilsen; Hansen, Ailin Falkmo; Madssen, Erik; Wisløff, Ulrik; Brumpton, Ben Michael. (2022) New genetic determinants of VO2max-level identified by GWAS: The HUNT Study. Frontiers in Cardiovascular Biomedicine 2022-04-29 - 2022-05-01
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PosterSæther, Julie Caroline; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Brune; Gjære, Sigrid. (2022) Small LDL-5 subfractions are associated with coronary atherosclerosis despite no differences in conventional lipids. European Atherosclerosis Society EAS Congress 2022 , Milano 2022-05-22 - 2022-05-25
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PosterKlevjer, Marie; Nordeidet, Ada Nilsen; Bye, Anja. (2022) Genome-wide association study indentify new genetic determinants of resting heart rate. Nordic Society of Human Genetics and Precision Medicine 2022-11-03 - 2022-11-04
2020
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ProgramdeltagelseKlevjer, Marie. (2020) Vi har lenge mistenkt at kondis går i arv. Nå er det bevist.» . NRK P2 - Studio 2 NRK P2 - Studio 2 [Radio] 2020-03-04
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Vitenskapelig foredragKlevjer, Marie; Brumpton, Ben Michael; Madssen, Erik; Bye, Anja. (2020) Identifying new genetic markers for maximal oxygen uptake. EPINOR EPINOR Online Conference 2020-11-09 - 2020-11-09
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PosterKlevjer, Marie; Sæther, Julie Caroline; Vesterbekkmo, Elisabeth Kleivhaug; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Bruna. (2020) LDL-5 are elevated in patients with coronary atherosclerosis, despite no increase in total levels of LDL-cholesterol. European Society of Cardiology ESC Congress 2020 - The digital experience 2020-08-29 - 2020-09-01
2019
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Vitenskapelig foredragBye, Anja; Klevjer, Marie; Ryeng, Einar; da Silva, Gustavo Justo; Moreira, Jose Bianco Nascimento; Stensvold, Dorthe. (2019) Identification of genetic variants associated with the cardiovascular disease risk factor, low aerobic fitness - The HUNT study. European Society of Cardiology European Society of Cardiology Congress 2019 , Paris 2019-08-30 - 2019-09-05