Gøril Rolfseng Grøntvedt
Om
Seksjonsoverlege ved avdeling for nevrologi og nevrofysiologi, St Olavs Hospital. Som overlege jobber jeg først og fremst med nevrodegenerative sykdommer/Alzheimers sykdom og utredning av mistenkt kognitiv svikt blant yngre.
Førsteamanuensis ved Institutt for nevromedisin og bevegelsesforstyrrelser og Kavli-intistuttet, NTNU. Som kliniker i forskningsgruppen Trønderbrain og Jebsen senter for Alzheimers sykdom er hovedoppgaven å rekruttere, utrede og selektere egnede pasienter til ulike forskningsprosjekter.
Egen forskning har hatt hovedfokus på ulike biomarkører i spinalvæske ved Alzheimers sykdom.
Forskning
Forskningsfokuset til Trønderbrain er å fostå molekylære prosesser som starter og fører til progresjon av nevrodegenerative sykdommer med spesielt fokus på Alzheimers sykdom.
Målet er å identifisere nye biomarkører som kan bidra til tidlig diagnose, forståelse av sykdomsprosesser og å finne mål for effektiv terapi.
Gruppen består av forskere og klinikere som sammen kan bygge bro mellom grunnleggende forskning i celle-og dyremodeller og klinisk forskning på mennesker.
Publikasjoner
2024
-
Swift, Imogen J.;
Rademakers, Rosa;
Finch, NiCole;
Baker, Matt;
Ghidoni, Roberta;
Benussi, Luisa.
(2024)
A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Knudtzon, Stephanie;
Nordengen, Kaja;
Grøntvedt, Gøril Rolfseng;
Jarholm, Jonas Alexander;
Eliassen, Ingvild Vøllo;
Selnes, Per.
(2024)
Age-adjusted CSF t-tau and NfL do not improve diagnostic accuracy for prodromal Alzheimer’s Disease.
Neurobiology of Aging
Vitenskapelig artikkel
2023
-
Jarholm, Jonas Alexander;
Bjørnerud, Atle;
Dalaker, Turi Olene;
Sadat Akhavi, Mehdi;
Kirsebom, Bjørn-Eivind;
Pålhaugen, Lene.
(2023)
Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Bøen, Rune;
Kaufmann, Tobias Herbert;
van der Meer, Dennis;
Frei, Oleksandr;
Agartz, Ingrid;
Ames, David.
(2023)
Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers.
Biological Psychiatry
Vitenskapelig artikkel
-
Hemminghyth, Mathilde Suhr;
Chwiszczuk, Luiza;
Breitve, Monica Haraldseid;
Gisladottir, Berglind;
Grøntvedt, Gøril Rolfseng;
Nakling, Arne Exner.
(2023)
Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults.
Neurobiology of Aging
Vitenskapelig artikkel
-
Nordengen, Kaja;
Kirsebom, Bjørn-Eivind Seljelid;
Richter, Grit;
Pålhaugen, Lene;
Gisladottir, Berglind;
Siafarikas, Nikias Ioannis.
(2023)
Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease.
Journal of Neuroinflammation
Vitenskapelig artikkel
2022
-
Giannisis, Andreas;
Al-Grety, Asma;
Carlsson, Henrik;
Patra, Kalicharan;
Twohig, Daniel;
Sando, Sigrid Botne.
(2022)
Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Bråthen, Geir;
White, Linda Rosemary;
Salvesen, Øyvind.
(2022)
Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden.
JAMA Network Open
Vitenskapelig artikkel
2021
-
Lim, Bryant;
Grøntvedt, Gøril Rolfseng;
Bathala, Pradeepthi;
Kale, Shraddha S.;
Campbell, Christopher T.;
Stengelin, Martin.
(2021)
CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia.
Neurobiology of Aging
Vitenskapelig artikkel
2020
-
Grøntvedt, Gøril Rolfseng;
Lauridsen, Camilla;
Berge, Guro;
White, Linda Rosemary;
Salvesen, Øyvind;
Bråthen, Geir.
(2020)
The Amyloid, Tau, and Neurodegeneration (A/T/N) Classification Applied to a Clinical Research Cohort with Long-Term Follow-Up .
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Lim, Bryant;
Sando, Sigrid Botne;
Grøntvedt, Gøril Rolfseng;
Bråthen, Geir;
Diamandis, Eleftherios P..
(2020)
Cerebrospinal fluid neuronal pentraxin receptor as a biomarker of long-term progression of Alzheimer's disease: a 24-month follow-up study.
Neurobiology of Aging
Vitenskapelig artikkel
2019
-
Kirsebom, Bjørn-Eivind;
Espenes, Ragna;
Hessen, Erik;
Waterloo, Knut;
Johnsen, Stein Harald;
Gundersen, Elisabeth.
(2019)
Demographically adjusted CERAD wordlist test norms in a Norwegian sample from 40 to 80 years.
The Clinical Neuropsychologist
Vitenskapelig artikkel
-
Nordengen, Kaja;
Kirsebom, Bjørn-Eivind;
Henjum, Kristi;
Selnes, Per;
Gisladottir, Berglind;
Wettergreen, Marianne.
(2019)
Glial activation and inflammation along the Alzheimer's disease continuum.
Journal of Neuroinflammation
Vitenskapelig artikkel
-
Patra, Kalicharan;
Giannisis, Andreas;
Edlund, Anna K.;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Berge, Guro.
(2019)
Plasma apolipoprotein E monomer and dimer profile and relevance to Alzheimer's disease.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
2018
-
Grøntvedt, Gøril Rolfseng;
Schröder, Tobias Navarro;
Sando, Sigrid Botne;
White, Linda Rosemary;
Bråthen, Geir;
Doeller, Christian.
(2018)
Alzheimer's disease.
Current Biology
Populærvitenskapelig artikkel
-
Twohig, Daniel;
Rodriguez-Vieitez, Elena;
Sando, Sigrid Botne;
Berge, Guro;
Lauridsen, Camilla;
Møller, Ina.
(2018)
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.
Acta neuropathologica communications
Vitenskapelig artikkel
-
Patra, Kalicharan;
Soosaipillai, Antoninus;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Berge, Guro;
Møller, Ina.
(2018)
Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Navarro Schröder, Tobias;
Sando, Sigrid Botne;
Bråthen, Geir;
White, Linda Rosemary;
Doeller, Christian Fritz Andreas.
(2018)
Alzheimer´s disease.
Current Biology
Populærvitenskapelig artikkel
2017
-
Lauridsen, Camilla;
Sando, Sigrid Botne;
Møller, Ina;
Berge, Guro;
Pomary, Precious Kwadzo;
Grøntvedt, Gøril Rolfseng.
(2017)
Cerebrospinal fluid Aβ43 is reduced in early-onset compared to late-onset Alzheimer's disease, but has similar diagnostic accuracy to Aβ42.
Frontiers in Aging Neuroscience
Vitenskapelig artikkel
-
Fladby, Tormod;
Pålhaugen, Lene;
Selnes, Per;
Waterloo, Knut;
Bråthen, Geir;
Hessen, Erik.
(2017)
Detecting at-risk Alzheimer's disease cases.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
2016
-
Berge, Guro;
Sando, Sigrid Botne;
Albrektsen, Grethe;
Lauridsen, Camilla;
Møller, Ina;
Grøntvedt, Gøril Rolfseng.
(2016)
Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer's disease, mild cognitive impairment, or healthy controls: a two year follow-up study.
BMC Neurology
Vitenskapelig artikkel
-
Lauridsen, Camilla;
Sando, Sigrid Botne;
Shabnam, Adiba;
Møller, Ina;
Berge, Guro;
Grøntvedt, Gøril Rolfseng.
(2016)
Cerebrospinal Fluid Levels of Amyloid Beta 1-43 in Patients with Amnestic Mild Cognitive Impairment or Early Alzheimer's Disease: A 2-Year Follow-Up Study.
Frontiers in Aging Neuroscience
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Swift, Imogen J.;
Rademakers, Rosa;
Finch, NiCole;
Baker, Matt;
Ghidoni, Roberta;
Benussi, Luisa.
(2024)
A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Knudtzon, Stephanie;
Nordengen, Kaja;
Grøntvedt, Gøril Rolfseng;
Jarholm, Jonas Alexander;
Eliassen, Ingvild Vøllo;
Selnes, Per.
(2024)
Age-adjusted CSF t-tau and NfL do not improve diagnostic accuracy for prodromal Alzheimer’s Disease.
Neurobiology of Aging
Vitenskapelig artikkel
-
Jarholm, Jonas Alexander;
Bjørnerud, Atle;
Dalaker, Turi Olene;
Sadat Akhavi, Mehdi;
Kirsebom, Bjørn-Eivind;
Pålhaugen, Lene.
(2023)
Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Bøen, Rune;
Kaufmann, Tobias Herbert;
van der Meer, Dennis;
Frei, Oleksandr;
Agartz, Ingrid;
Ames, David.
(2023)
Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers.
Biological Psychiatry
Vitenskapelig artikkel
-
Hemminghyth, Mathilde Suhr;
Chwiszczuk, Luiza;
Breitve, Monica Haraldseid;
Gisladottir, Berglind;
Grøntvedt, Gøril Rolfseng;
Nakling, Arne Exner.
(2023)
Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults.
Neurobiology of Aging
Vitenskapelig artikkel
-
Nordengen, Kaja;
Kirsebom, Bjørn-Eivind Seljelid;
Richter, Grit;
Pålhaugen, Lene;
Gisladottir, Berglind;
Siafarikas, Nikias Ioannis.
(2023)
Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease.
Journal of Neuroinflammation
Vitenskapelig artikkel
-
Giannisis, Andreas;
Al-Grety, Asma;
Carlsson, Henrik;
Patra, Kalicharan;
Twohig, Daniel;
Sando, Sigrid Botne.
(2022)
Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Bråthen, Geir;
White, Linda Rosemary;
Salvesen, Øyvind.
(2022)
Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden.
JAMA Network Open
Vitenskapelig artikkel
-
Lim, Bryant;
Grøntvedt, Gøril Rolfseng;
Bathala, Pradeepthi;
Kale, Shraddha S.;
Campbell, Christopher T.;
Stengelin, Martin.
(2021)
CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia.
Neurobiology of Aging
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Lauridsen, Camilla;
Berge, Guro;
White, Linda Rosemary;
Salvesen, Øyvind;
Bråthen, Geir.
(2020)
The Amyloid, Tau, and Neurodegeneration (A/T/N) Classification Applied to a Clinical Research Cohort with Long-Term Follow-Up .
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Lim, Bryant;
Sando, Sigrid Botne;
Grøntvedt, Gøril Rolfseng;
Bråthen, Geir;
Diamandis, Eleftherios P..
(2020)
Cerebrospinal fluid neuronal pentraxin receptor as a biomarker of long-term progression of Alzheimer's disease: a 24-month follow-up study.
Neurobiology of Aging
Vitenskapelig artikkel
-
Kirsebom, Bjørn-Eivind;
Espenes, Ragna;
Hessen, Erik;
Waterloo, Knut;
Johnsen, Stein Harald;
Gundersen, Elisabeth.
(2019)
Demographically adjusted CERAD wordlist test norms in a Norwegian sample from 40 to 80 years.
The Clinical Neuropsychologist
Vitenskapelig artikkel
-
Nordengen, Kaja;
Kirsebom, Bjørn-Eivind;
Henjum, Kristi;
Selnes, Per;
Gisladottir, Berglind;
Wettergreen, Marianne.
(2019)
Glial activation and inflammation along the Alzheimer's disease continuum.
Journal of Neuroinflammation
Vitenskapelig artikkel
-
Patra, Kalicharan;
Giannisis, Andreas;
Edlund, Anna K.;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Berge, Guro.
(2019)
Plasma apolipoprotein E monomer and dimer profile and relevance to Alzheimer's disease.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Schröder, Tobias Navarro;
Sando, Sigrid Botne;
White, Linda Rosemary;
Bråthen, Geir;
Doeller, Christian.
(2018)
Alzheimer's disease.
Current Biology
Populærvitenskapelig artikkel
-
Twohig, Daniel;
Rodriguez-Vieitez, Elena;
Sando, Sigrid Botne;
Berge, Guro;
Lauridsen, Camilla;
Møller, Ina.
(2018)
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.
Acta neuropathologica communications
Vitenskapelig artikkel
-
Patra, Kalicharan;
Soosaipillai, Antoninus;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Berge, Guro;
Møller, Ina.
(2018)
Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Navarro Schröder, Tobias;
Sando, Sigrid Botne;
Bråthen, Geir;
White, Linda Rosemary;
Doeller, Christian Fritz Andreas.
(2018)
Alzheimer´s disease.
Current Biology
Populærvitenskapelig artikkel
-
Lauridsen, Camilla;
Sando, Sigrid Botne;
Møller, Ina;
Berge, Guro;
Pomary, Precious Kwadzo;
Grøntvedt, Gøril Rolfseng.
(2017)
Cerebrospinal fluid Aβ43 is reduced in early-onset compared to late-onset Alzheimer's disease, but has similar diagnostic accuracy to Aβ42.
Frontiers in Aging Neuroscience
Vitenskapelig artikkel
-
Fladby, Tormod;
Pålhaugen, Lene;
Selnes, Per;
Waterloo, Knut;
Bråthen, Geir;
Hessen, Erik.
(2017)
Detecting at-risk Alzheimer's disease cases.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Berge, Guro;
Sando, Sigrid Botne;
Albrektsen, Grethe;
Lauridsen, Camilla;
Møller, Ina;
Grøntvedt, Gøril Rolfseng.
(2016)
Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer's disease, mild cognitive impairment, or healthy controls: a two year follow-up study.
BMC Neurology
Vitenskapelig artikkel
-
Lauridsen, Camilla;
Sando, Sigrid Botne;
Shabnam, Adiba;
Møller, Ina;
Berge, Guro;
Grøntvedt, Gøril Rolfseng.
(2016)
Cerebrospinal Fluid Levels of Amyloid Beta 1-43 in Patients with Amnestic Mild Cognitive Impairment or Early Alzheimer's Disease: A 2-Year Follow-Up Study.
Frontiers in Aging Neuroscience
Vitenskapelig artikkel
Formidling
Podcast Diagnose Alzheimers sykdom
Ta vare på hjernen
Adressasamtalen
2024
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PosterEgiazarian, Milena Armenovna; Abentung, Andreas; Karabeika, Emily; Hanumaihgari, Priyanka; Schnur, Paulina; Hovland, Oline Øie. (2024) The role of impaired oxidative base lesion repair in Alzheimer's disease . Alzheimer's Association International Conference 2024-07-28 - 2024-08-01
2023
-
PosterHemminghyth, Mathilde Suhr; Breitve, Monica Haraldseid; Gisladottir, Berglind; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Fladby, Tormod. (2023) Cerebrospinal fluid neurofilament light chain mediates age-related decline in learning and memory in healthy adults. AAIC Alzheimer's Association International Conference , Amsterdam 2023-07-14 - 2023-07-20
2022
-
PosterBecu, Marcia Constance Noemi; Bonnevie, Tora; Polti, Ignacio; Jarholm, Jonas Alexander; Grøntvedt, Gøril Rolfseng; Bråthen, Geir. (2022) Entorhinal grid-like representation in early Alzheimer's disease: association with biomarkers concentration and genetic risk. Society for Neuroscience 2022 2022-11-12 - 2022-11-12
2017
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PosterLauridsen, Camilla; Sando, Sigrid Botne; Møller, Ina; Berge, Guro; Pomary, Precious Kwadzo; Grøntvedt, Gøril Rolfseng. (2017) Cerebrospinal fluid levels of Aβ43 are significantly decreased in patients with early-onset compared to late-onset Alzheimer’s disease. AD/PD The 13th International Conference on Alzheimer's and Parkinson's Diseases (ADPD) , Wien 2017-03-29 - 2017-04-02