Nicolai Winter-Hjelm
Om
Jeg jobber i gruppen for Integrert Nevrovitenskap, hvor jeg fullførte en doktorgrad i medisin i september 2024 under veiledning av Professor Ioanna Sandvig. I forskningen min har jeg også samarbeidet tett med Professor Pawel Sikorski (medveileder) ved institutt for fysikk, og Professor Axel Sandvig (mentor) ved institutt for nevromedisin og bevegelsesvitenskap. I tillegg har jeg hatt en 25% stilling som pliktarbeider ved NTNU NanoLab, hvor jeg har bidratt med teknisk støtte og hjelp til brukere.
For mer informasjon om gruppen vår og det vi jobber med, besøk gjerne gruppesiden vår.
Verv
08.2023 - 07.2024: Representant for midlertidig ansatte i NTNUs styre.
Akademisk Bakgrunn
08.2020 - 09.2024: Ph.D. i medisin, NTNU
01.2019 - 05.2019: Biologiske studier, utveksling, NTU Singapore
08.2015 - 06.2020: Master i Nanoteknologi (MSc), NTNU
Kompetanseord
Forskning
I arbeidet mitt håper jeg å kunne kaste mer lys over følgende spørsmål:
- Hvordan påvirker topologien (i.e. strukturen) til nevrale nettverk funksjonen og den komputasjonelle kapasiteten til nettverkene?
- Hvordan påvirker endringer på mikro- og mesoskala, grunnet f.eks. skade eller sykdom, funksjonaliteten til nevrale nettverk?
For å besvare disse spørsmålene jobber jeg med å utvikle neste generasjons mikrofluidiske systemer koblet til mikroelektrode-matriser for applikasjon i nevrovitenskap ved hjelp av infrastrukturen og ekspertisen ved NTNU NanoLab. Videre bruker jeg disse plattformene til å studere funksjonen til friske og skadede/syke nevrale nettverk. Som et eksempel på sistnevnte jobber jeg blant annet i samarbeid med dyktige kollegaer med å utvikle bedre modellsystemer til å studere sykdommer som Alzheimer og ALS. Vårt håp er at slike modellsystemer kan gi oss en bedre forståelse for hvordan slike sykdommer oppstår og sprer seg i nervesystemet, og ikke minst hvordan vi kan oppdage dem tidlig nok til å stanse dem før det er for sent.
Dette arbeidet er en høyst interdisiplinær innsats i krysningen mellom nevrovitenskap, nanoteknologi, biofysikk, datavitenskap og matematikk. Mitt håp er at dette arbeidet vil bidra til videre progresjon innen sykdom/pasient-spesifikk modellering av nevrodegenerative sykdommer og traumatiske skader i sentralnervesystemet, og muliggjøre testing/screening av relevante behandlinger/medisiner.
Publikasjoner
Structure-Function Dynamics of Engineered, Modular Neuronal Networks with Controllable Afferent-Efferent Connectivity
Engineered cortical microcircuits for investigations of neuroplasticity
Functional Complexity of Engineered Neural Networks Self-Organized on Novel 3D Interfaces
Nanoporous Platinum Microelectrode Arrays for Neuroscience Applications
Reverse Engineering of Feedforward Cortical-Hippocampal Microcircuits for Modelling Neural Network Function and Dysfunction
Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation
2024
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Winter-Hjelm, Nicolai;
Sandvig, Ioanna;
Sandvig, Axel;
Sikorski, Pawel.
(2024)
Bioengineered Neural Networks as Computational Systems. Designing Anatomically Inspired Microcircuits to Decode Neural Function and Dysfunction .
Doctoral theses at NTNU (355)
Doktorgradsavhandling
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Winter-Hjelm, Nicolai;
Klausen, Kasper;
Normann, Amund Stensrud;
Sandvig, Axel;
Sandvig, Ioanna;
Sikorski, Pawel.
(2024)
Functional Complexity of Engineered Neural Networks Self-Organized on Novel 3D Interfaces.
bioRxiv
Vitenskapelig artikkel
-
Fiskum, Vegard;
Winter-Hjelm, Nicolai;
Christiansen, Nicholas;
Sandvig, Axel;
Sandvig, Ioanna.
(2024)
ALS patient-derived motor neuron networks exhibit microscale dysfunction and mesoscale compensation rendering them highly vulnerable to perturbation.
bioRxiv
Vitenskapelig artikkel
-
Winter-Hjelm, Nicolai;
Isdal, Leik;
Köllensperger, Peter;
Sandvig, Axel;
Sandvig, Ioanna;
Sikorski, Pawel Tadeusz.
(2024)
Nanoporous Platinum Microelectrodes for Neuroscience Applications.
bioRxiv
Vitenskapelig artikkel
-
Winter-Hjelm, Nicolai;
Sikorski, Pawel Tadeusz;
Sandvig, Axel;
Sandvig, Ioanna.
(2024)
Engineered cortical microcircuits for investigations of neuroplasticity.
Lab on a Chip
Vitenskapelig artikkel
-
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Niethammer, Salome Nora;
Kobro-Flatmoen, Asgeir;
Witter, Menno Peter;
Sandvig, Axel.
(2024)
Reverse engineering of feedforward cortical-hippocampal microcircuits for modelling neural network function and dysfunction.
Scientific Reports
Vitenskapelig artikkel
2023
-
Winter-Hjelm, Nicolai;
Tomren, Åste Brune;
Sikorski, Pawel Tadeusz;
Sandvig, Axel;
Sandvig, Ioanna.
(2023)
Structure-function dynamics of engineered, modular neuronal networks with controllable afferent-efferent connectivity.
Journal of Neural Engineering
Vitenskapelig artikkel
-
Weir, Janelle Shari;
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Sandvig, Axel;
Sandvig, Ioanna.
(2023)
Altered structural organization and functional connectivity in feedforward neural networks after induced perturbation.
bioRxiv
Vitenskapelig artikkel
Tidsskriftspublikasjoner
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Winter-Hjelm, Nicolai;
Klausen, Kasper;
Normann, Amund Stensrud;
Sandvig, Axel;
Sandvig, Ioanna;
Sikorski, Pawel.
(2024)
Functional Complexity of Engineered Neural Networks Self-Organized on Novel 3D Interfaces.
bioRxiv
Vitenskapelig artikkel
-
Fiskum, Vegard;
Winter-Hjelm, Nicolai;
Christiansen, Nicholas;
Sandvig, Axel;
Sandvig, Ioanna.
(2024)
ALS patient-derived motor neuron networks exhibit microscale dysfunction and mesoscale compensation rendering them highly vulnerable to perturbation.
bioRxiv
Vitenskapelig artikkel
-
Winter-Hjelm, Nicolai;
Isdal, Leik;
Köllensperger, Peter;
Sandvig, Axel;
Sandvig, Ioanna;
Sikorski, Pawel Tadeusz.
(2024)
Nanoporous Platinum Microelectrodes for Neuroscience Applications.
bioRxiv
Vitenskapelig artikkel
-
Winter-Hjelm, Nicolai;
Sikorski, Pawel Tadeusz;
Sandvig, Axel;
Sandvig, Ioanna.
(2024)
Engineered cortical microcircuits for investigations of neuroplasticity.
Lab on a Chip
Vitenskapelig artikkel
-
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Niethammer, Salome Nora;
Kobro-Flatmoen, Asgeir;
Witter, Menno Peter;
Sandvig, Axel.
(2024)
Reverse engineering of feedforward cortical-hippocampal microcircuits for modelling neural network function and dysfunction.
Scientific Reports
Vitenskapelig artikkel
-
Winter-Hjelm, Nicolai;
Tomren, Åste Brune;
Sikorski, Pawel Tadeusz;
Sandvig, Axel;
Sandvig, Ioanna.
(2023)
Structure-function dynamics of engineered, modular neuronal networks with controllable afferent-efferent connectivity.
Journal of Neural Engineering
Vitenskapelig artikkel
-
Weir, Janelle Shari;
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Sandvig, Axel;
Sandvig, Ioanna.
(2023)
Altered structural organization and functional connectivity in feedforward neural networks after induced perturbation.
bioRxiv
Vitenskapelig artikkel
Rapport
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Winter-Hjelm, Nicolai;
Sandvig, Ioanna;
Sandvig, Axel;
Sikorski, Pawel.
(2024)
Bioengineered Neural Networks as Computational Systems. Designing Anatomically Inspired Microcircuits to Decode Neural Function and Dysfunction .
Doctoral theses at NTNU (355)
Doktorgradsavhandling
Undervisning
Emner
Veiledning
Nåværende og tidligere masterstudenter:
2023 - 2024
- Marie Wahlstrøm - "Investigating PACMA31 as a Potential Inhibitor for NO-Induced Growth Cone Collapse of In Vitro Neural Networks"
2022 - 2023
- Polina Malahov - "Using Advanced Microfluidic Models to Study Structure-Function Dynamics in Healthy and Perturbed Neural Networks In Vitro"
- Kasper Klaussen - "Microelectrode Arrays Interfaced with SU-8 3050 3D Microscaffolds for Neuroscience Applications"
2021 - 2022
- Åste Brune Tomren - "Using Microfluidics and 3D Surfaces to Increase the Physiological Translatability of In Vitro Neuronal Networks"
- Amund Stensrud Normann - "Fabrication of 3D Surfaces for Enhanced Physiological Translatability of In Vitro Neuronal Network Models Using Inclined Lithography of SU-8 3050"
- Truels Lone - "Controlling Structure-Function Dynamics of Neuronal Networks using Microfluidics"
2020 - 2021
- Nienke Laura de Jong - "An In Vitro Microfluidic Neural Network Model for Unidirectional Axonal Growth"
- Edevard Hvide - "Effects of Nanostructured SU-8 Surfaces on Neurons and Neural Networks in Vitro"
- Leik Isdal - "Developing 2.5D Nanotopographical in vitro Neural Network Recording Platform to Mimic the Physical Environment of the Brain"
- Aleksandar Kavazov - "Fabrication of platinum mushroom-shaped microelectrode array for in vitro studies of neural networks and neural network pathologies"
Formidling
2024
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Sandvig, Axel; Sikorski, Pawel; Sandvig, Ioanna. (2024) Engineered Cortical Microcircuits for Investigations of Neuroplasticity. TNNN TNNN Conference 2024 , Oslo 2024-06-06 - 2024-06-08
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PosterFiskum, Vegard; Winter-Hjelm, Nicolai; Christiansen, Nicholas; Sandvig, Axel; Sandvig, Ioanna. (2024) Deciphering micro-and mesoscale dynamics in ALS patient-derived motor neuron networks. University of Copenhagen 4th Nordic Neuroscience Meeting , Copenhagen, Denmark 2024-01-15 - 2024-01-17
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PosterWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks . Maxwell Biosystems 4th In-Vitro 2D & 3D Neuronal Networks Summit , Zürich 2024-04-08 - 2024-04-10
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PosterWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Fiskum, Vegard; Kollstrøm, Anna Mikalsen; Christiansen, Nicholas; Sandvig, Axel. (2024) Reverse engineered neural circuit motifs as computational substrates. FENS & Lundbeck Foundation The Brain Conference - Circuits for Movement , Rungstedgaard 2024-06-16 - 2024-06-19
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Maxwell Biosystems 4th In-Vitro 2D & 3D Neuronal Networks Summit , Zürich, Switzerland 2024-04-08 - 2024-04-10
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PosterWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Nordic NanoLab Network Nordic NanoLab User Meeting 2024 , Oslo 2024-06-03 - 2024-06-04
2023
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Klausen, Kasper Grøndahl; Normann, Amund Stensrud; Sandvig, Axel; Sandvig, Ioanna; Sikorski, Pawel. (2023) Novel 3D Interfaces for Enhancing the Electrophysiological Complexity of Engineered Neuronal Networks . NRSN Norwegian Research School for Neuroscience 10th NRSN Conference 2023-09-27 - 2023-09-29
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Klausen, Kasper Grøndahl; Normann, Amund Stensrud; Sandvig, Axel; Sandvig, Ioanna; Sikorski, Pawel. (2023) Novel 3D Interfaces with Embedded Nanoporous Microelectrodes for Preclinical Neuroscience Research. TNNN TNNN Conference 2023 2023-06-21 - 2023-06-23
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PosterWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Tomren, Åste Brune; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2023) Engineered Multi-Nodal Neuronal Networks with Predefined Afferent-Efferent Connectivity for Advanced Modelling of Network Function and Dysfunction. European Biophysical Societies' Association 14th EBSA Congress , Stockholm 2023-07-31 - 2023-08-04
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2023) Advanced Engineering Approaches for Recapitulating Structure-Function Dynamics of Neuronal Networks In Vitro . YROCK & NeuroSYS NeuroSYS 2023 2023-04-06 - 2023-04-06
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Vitenskapelig foredragHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Witter, Menno Peter; Kobro-Flatmoen, Asgeir; Sandvig, Axel. (2023) Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling . Norwegian Research School in Neuroscience (NRSN) 10th Annual PhD Conference in Neuroscience , Egersund, Stavanger, Norway 2023-09-27 - 2023-09-29
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PosterHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Witter, Menno Peter; Kobro-Flatmoen, Asgeir; Sandvig, Axel. (2023) An in vitro platform to study entorhinal-hippocampal neuronal networks. AD/PD kenes 17th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD) , Gothenburg, Sweden 2023-03-28 - 2023-04-01
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Vitenskapelig foredragHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Sandvig, Axel. (2023) Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling. Norwegian Research School in Neuroscience (NRSN) NRSN Norwegian Research School for Neuroscience 10th NRSN Conference , Egersund 2023-09-27 - 2023-09-29
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PosterØvreeide, Ingrid Haga; Szydlak, Renata; Zemla, Joanna; Luty, Marcin; Monaldi, Jessica; Hines, Thomas G.. (2023) Micro- and nanofabrication for biophysics and biomedical research. NTNU Health, NTNU Nano, and NTNU Biotechnology Sensor Day , Trondheim 2023-04-26 - 2023-04-26
2022
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Faglig foredragWinter-Hjelm, Nicolai. (2022) Advancing the Frontier of Neuroscience with Engineered Neural Networks. Guest Lecture, NTNU Nanomechanical Lab 2022-05-03 - 2022-05-03
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PosterWinter-Hjelm, Nicolai; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2022) Next-Generation Microfluidics Interfaced with Microelectrode Arrays for Neuroscience Applications. Nordic NanoLab Network Nordic NanoLab User Meeting , Chalmers University of Technology 2022-05-05 - 2022-05-06
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2022) Advancing the Frontier of Neuroscience with Engineered Neural Networks. NTNU Nano NTNU Nano Lecture 2022-03-09 - 2022-03-09
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2022) Advanced Engineering Approaches for Recapitulation of Structure-Function Dynamics in Neuronal Networks . TNNN TNNN 2022-11-30 - 2022-12-02
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Vitenskapelig foredragHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna. (2022) An in vitro platform to study entorhinal-hippocampal neural networks . Norwegian Research School for Neuroscience 9th NRSN Conference , Stiklestad 2022-09-28 - 2022-09-30
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PosterWinter-Hjelm, Nicolai; Tomren, Åste Brune; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2022) Advanced Engineering Approaches for Recapitulation of Structure-Function Dynamics in Neural Networks . NRSN 9th NRSN Conference 2022-09-28 - 2022-09-30
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PosterHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna. (2022) An in vitro platform to study adult entorhinal entorhinal-hippocampal neuronal circuits in early Alzheimer's disease. NTNU, Kyoto University JANUBET Symposiym , Kyoto 2022-09-20 - 2022-09-24
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Faglig foredragWinter-Hjelm, Nicolai. (2022) Konstruksjon av Biologiske Nevrale Designernettverk til Bruk i Forskning på Hjernen og Hjernesykdommer . Introuker MTNANO 2022 2022-08-18 - 2022-08-18
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PosterWinter-Hjelm, Nicolai; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2022) Advanced Engineering Approaches for Recapitulation of Structure-Function Dynamics in Neuronal Networks. FENS FENS Forum 2022 , Paris 2022-07-09 - 2022-07-13
2021
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2021) Engineered Neural Networks as Computational Substrates. NTNU NanoLab NTNU NanoLab Lunch Talk 2021-11-10 - 2021-11-10
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2021) Controlling the Flow of Information in Neuronal Networks Through the use of Customized Microfluidics. NTNU Nano Norwegian NanoSymposium 2021 2021-10-05 - 2021-10-06
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PosterWinter-Hjelm, Nicolai; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2021) Engineered Neural Networks as Computational Substrates. NRSN NRSN National Neuroscience Symposium 2021 2021-06-29 - 2021-07-01
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Faglig foredragWinter-Hjelm, Nicolai. (2021) Biologiske Nevrale Designernettverk . Introuker MTNANO 2021 2021-08-17 - 2021-08-17