Katrine Sjaastad Hanssen
Om
Jeg jobber som forsker i Sandvig-gruppen for Integrativ Nevrovitenskap ved Institutt for Nevromedisin og Bevegelsesvitenskap, NTNU. I min doktorgrad har jeg jobbet med integrering av avanserte nevrale nettverksmodeller for å studere Alzheimer sykdom på et tidlig sykdomsstadie. I min nåværende forskersstilling jobber jeg med både grunnforskning og klinisk forskning innenfor fagfeltet Alzheimer sykdom.
Forskningsfokus:
1) Inflammatorisk respons og patologi i tidlige sykdomsstadier av Alzheimer.
2) Kritiske tidspunkt hvor strukturelle og funksjonelle endringer i Alzheimer-nettverk oppstår.
Klinisk forskning:
1) Bedre forstå de ulike stadiene av Alzheimer demens og deres sammenheng med svekket semantisk hukommelse.
Mer om vår arbeid med MemAD-studien kan du finne her: MemAD-studien - Forskning i kampen mot Alzheimer sykdom.
Metoder:
Hovedmetoder og verktøy jeg bruker i min forskning innebærer nevrale nettverksmodeller med pasientspesifikke celler fra pasienter med Alzheimer og friske kontroller, elektrofysiologi, immunocytokjemi, MR-skanning, EEG-undersøkelser og kognitiv testing.
Forskningsformidling:
Ved siden av labarbeid, artikkelskriving og undervisning har jeg en stor lidenskap for forskningsformidling om demens og Alzheimer ut til befolkningen. Jeg har tidligere holdt foredrag til pasienter og pårørende ved fagforeninger, på en teaterfestival, ved ressurssenter for demens og til lokale demensforeninger bl.a,.
Bakgrunn:
2019-2023: PhD i Medisin og Helsevitenskap, KISN/INB, NTNU
2017-2019: Mastergrad i Nevrovitenskap, KISN, NTNU
2014-2017: Bachelorgrad i Bevegelsesvitenskap, NTNU/Aarhus Universitet
Publikasjoner
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice
Reverse Engineering of Feedforward Cortical-Hippocampal Microcircuits for Modelling Neural Network Function and Dysfunction
Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation
2024
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Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Niethammer, Salome Nora;
Kobro-Flatmoen, Asgeir;
Witter, Menno Peter;
Sandvig, Axel.
(2024)
Reverse engineering of feedforward cortical-hippocampal microcircuits for modelling neural network function and dysfunction.
Scientific Reports
Vitenskapelig artikkel
2023
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Hanssen, Katrine Sjaastad;
Witter, Menno Peter;
Sandvig, Axel;
Sandvig, Ioanna;
Kobro-Flatmoen, Asgeir.
(2023)
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice.
Journal of Neuroscience Methods
Vitenskapelig artikkel
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Weir, Janelle Shari;
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Sandvig, Axel;
Sandvig, Ioanna.
(2023)
Altered structural organization and functional connectivity in feedforward neural networks after induced perturbation.
bioRxiv
Vitenskapelig artikkel
-
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Niethammer, Salome Nora;
Kobro-Flatmoen, Asgeir;
Witter, Menno Peter;
Sandvig, Axel.
(2023)
Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling.
bioRxiv
Vitenskapelig artikkel
-
Hanssen, Katrine Sjaastad;
Kobro-Flatmoen, Asgeir;
Sandvig, Ioanna;
Witter, Menno Peter.
(2023)
Dissecting the complexities of Alzheimer's disease. Engineering selectively vulnerable neural networks in vitro.
Norges teknisk-naturvitenskapelige universitet
Doctoral theses at NTNU (365)
Doktorgradsavhandling
Tidsskriftspublikasjoner
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Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Niethammer, Salome Nora;
Kobro-Flatmoen, Asgeir;
Witter, Menno Peter;
Sandvig, Axel.
(2024)
Reverse engineering of feedforward cortical-hippocampal microcircuits for modelling neural network function and dysfunction.
Scientific Reports
Vitenskapelig artikkel
-
Hanssen, Katrine Sjaastad;
Witter, Menno Peter;
Sandvig, Axel;
Sandvig, Ioanna;
Kobro-Flatmoen, Asgeir.
(2023)
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice.
Journal of Neuroscience Methods
Vitenskapelig artikkel
-
Weir, Janelle Shari;
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Sandvig, Axel;
Sandvig, Ioanna.
(2023)
Altered structural organization and functional connectivity in feedforward neural networks after induced perturbation.
bioRxiv
Vitenskapelig artikkel
-
Hanssen, Katrine Sjaastad;
Winter-Hjelm, Nicolai;
Niethammer, Salome Nora;
Kobro-Flatmoen, Asgeir;
Witter, Menno Peter;
Sandvig, Axel.
(2023)
Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling.
bioRxiv
Vitenskapelig artikkel
Rapport
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Hanssen, Katrine Sjaastad;
Kobro-Flatmoen, Asgeir;
Sandvig, Ioanna;
Witter, Menno Peter.
(2023)
Dissecting the complexities of Alzheimer's disease. Engineering selectively vulnerable neural networks in vitro.
Norges teknisk-naturvitenskapelige universitet
Doctoral theses at NTNU (365)
Doktorgradsavhandling
Undervisning
Emner
Underviser og eksaminator for NEVR3001.
Veiledning
Veiledning av nåværende og tidligere studenter:
2023 - i dag:
- PhD kandidat - Marthe B. Grønli
- MSc student - Nurinissa Ece Erik
- MSc student - Maya Louise Atieno Ibenfeldt
- MSc student - Trym Herre
2020 - 2021:
Formidling
Katrine (30) med fersk doktorgrad om Alzheimer
Doktorpromosjonen vår 2024 ved NTNU
Nasjonalforeningen for folkehelsen - Trøndelag
2024
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Populærvitenskapelig foredragHanssen, Katrine Sjaastad. (2024) Demens og Alzheimer sykdom - Hva er det som skjer i hjernen? . Ressurssenter for Demens og Kavli Insitituttet Alzheimer med Katrine S.Hanssen og Trd.Kommune Ressurssenter , Fred Kavli Bygget, Øya, Trondheim 2024-04-25 - 2024-04-25
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Vitenskapelig foredragHanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel; Sikorski, Pawel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Maxwell Biosystems Maxwell Summit 2024 , Zürich 2024-04-08 - 2024-04-10
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PosterWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks . Maxwell Biosystems 4th In-Vitro 2D & 3D Neuronal Networks Summit , Zürich 2024-04-08 - 2024-04-10
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PosterWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Fiskum, Vegard; Kollstrøm, Anna Mikalsen; Christiansen, Nicholas; Sandvig, Axel. (2024) Reverse engineered neural circuit motifs as computational substrates. FENS & Lundbeck Foundation The Brain Conference - Circuits for Movement , Rungstedgaard 2024-06-16 - 2024-06-19
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Faglig foredragHanssen, Katrine Sjaastad. (2024) Demens - Forløp, sykdomsprosesser og diagnose. Stjørdal Kommune Foredrag , Stjørdal Bosenter 2024-08-21 - 2024-08-21
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Vitenskapelig foredragHanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel; Sikorski, Pawel Tadeusz. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Maxwell Biosystems 4th In-Vitro 2D & 3D Neuronal Networks Summit , Zürich, Switzerland 2024-04-08 - 2024-04-10
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Populærvitenskapelig foredragHanssen, Katrine Sjaastad. (2024) Alzheimer sykdom - Hva er det som skjer i hjernen?. Nasjonalforeningen Grong Demensforening Åpent møte om Demens , Grong Hotell 2024-04-11 - 2024-04-11
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PosterHanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel; Sikorski, Pawel Tadeusz. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Maxwell Biosystems 4th In-Vitro 2D & 3D Neuronal Networks Summit , Zürich, Switzerland 2024-04-08 - 2024-04-10
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Maxwell Biosystems 4th In-Vitro 2D & 3D Neuronal Networks Summit , Zürich, Switzerland 2024-04-08 - 2024-04-10
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PosterWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Nordic NanoLab Network Nordic NanoLab User Meeting 2024 , Oslo 2024-06-03 - 2024-06-04
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PosterHanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel; Sikorski, Pawel Tadeusz. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Research School for Training the Next Generation of Micro- and Nanotechnology Researchers in Norway TNNN Conference 2024 , Oslo, Norway 2024-06-06 - 2024-06-08
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PosterHanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel; Sikorski, Pawel Tadeusz. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Nordic Nanolab Network Nordic NanoLab User Meeting 2024 , Oslo, Norway 2024-06-03 - 2024-06-04
2023
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PosterWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Tomren, Åste Brune; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2023) Engineered Multi-Nodal Neuronal Networks with Predefined Afferent-Efferent Connectivity for Advanced Modelling of Network Function and Dysfunction. European Biophysical Societies' Association 14th EBSA Congress , Stockholm 2023-07-31 - 2023-08-04
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Vitenskapelig foredragWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2023) Advanced Engineering Approaches for Recapitulating Structure-Function Dynamics of Neuronal Networks In Vitro . YROCK & NeuroSYS NeuroSYS 2023 2023-04-06 - 2023-04-06
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Populærvitenskapelig foredragHanssen, Katrine Sjaastad. (2023) Alzheimer sykdom . Parat, NTNU Årsmøte Parat , Digitalt 2023-03-22 - 2023-03-22
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Populærvitenskapelig foredragHanssen, Katrine Sjaastad. (2023) Demens; Alzheimer sykdom . Nordland Teater Vinterlysfestivalen 2023 , Mo I Rana 2023-02-15 - 2023-02-15
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Populærvitenskapelig foredragHanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir. (2023) Leve bedre med Alzheimer?. Kavli Insituttet, NTNU Medisin og helse Brain Awareness Week , Trondheim 2023-03-16 - 2023-03-16
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Vitenskapelig foredragHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Witter, Menno Peter; Kobro-Flatmoen, Asgeir; Sandvig, Axel. (2023) Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling . Norwegian Research School in Neuroscience (NRSN) 10th Annual PhD Conference in Neuroscience , Egersund, Stavanger, Norway 2023-09-27 - 2023-09-29
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PosterHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Witter, Menno Peter; Kobro-Flatmoen, Asgeir; Sandvig, Axel. (2023) An in vitro platform to study entorhinal-hippocampal neuronal networks. AD/PD kenes 17th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD) , Gothenburg, Sweden 2023-03-28 - 2023-04-01
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Vitenskapelig foredragHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Sandvig, Axel. (2023) Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling. Norwegian Research School in Neuroscience (NRSN) NRSN Norwegian Research School for Neuroscience 10th NRSN Conference , Egersund 2023-09-27 - 2023-09-29
2022
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PosterHanssen, Katrine Sjaastad; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir. (2022) An in vitro platform to study adult entorhinal networks in Alzheimer's disease. AD/PD 2022 , Barcelona 2022-03-15 - 2022-03-20
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Vitenskapelig foredragHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna. (2022) An in vitro platform to study entorhinal-hippocampal neural networks . Norwegian Research School for Neuroscience 9th NRSN Conference , Stiklestad 2022-09-28 - 2022-09-30
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PosterHanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna. (2022) An in vitro platform to study adult entorhinal entorhinal-hippocampal neuronal circuits in early Alzheimer's disease. NTNU, Kyoto University JANUBET Symposiym , Kyoto 2022-09-20 - 2022-09-24
2021
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PosterHanssen, Katrine Sjaastad; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir. (2021) An in vitro platform to study entorhinal networks in Alzheimer’s disease. NRSN NRSN National Neuroscience Symposium 2021-06-29 - 2021-07-01
2020
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PosterHanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno. (2020) Developing a novel in vitro platform to study neuronal networks relevant to Alzheimer’s disease. FENS FENS Forum 2020 , Glasgow/Virtual Forum 2020-07-11 - 2020-07-15
2019
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PosterHanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno. (2019) Establishing entorhinal cortex layer II neuron cultures as a tool for the investigation of early Alzheimer's disease related changes. Nordic Neuroscience 3rd Nordic Neuroscience Meeting 2019 , Helsinki 2019-06-12 - 2019-06-14