Denis Kaynov
Om
Denis Kainov tok sin doktorgrad ved Universitetet i Helsingfors i 2005. Han var postdoktor ved Institutet for genetikk og molekylær- og cellebiologi (IGBMC) fra 2005 til 2007 og ved CRP-Santé Luxembourg fra 2007 til 2009. Han var forsker og prosjektleder ved Universitetet i Helsingfors fra 2010 til 2016. Nå er han professor ved NTNU i Norge.
Forskning
Gruppen vår utvikler antivirale medikamentcocktailer for å målrette et bredt spekter av virus og deres medikamentresistente varianter.
Publikasjoner
2024
-
Ianevski, Aleksandr;
Frøysa, Irene Trøen;
Lysvand, Hilde;
Calitz, Carlemi;
Smura, Teemu;
Nilsen, Hans-Johnny.
(2024)
The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants.
Antiviral Research
Vitenskapelig artikkel
-
Halabitska, Iryna;
Petakh, Pavlo;
Kamyshna, Iryna;
Oksenych, Valentyn;
Kainov, Denis;
Kamyshnyi, Oleksandr.
(2024)
The interplay of gut microbiota, obesity, and depression: insights and interventions.
Cellular and Molecular Life Sciences (CMLS)
Vitenskapelig oversiktsartikkel/review
2023
-
Wang, Yining;
Li, Pengfei;
Xu, Lei;
de Vries, Annemarie C.;
Rottier, Robbert J.;
Wang, Wenshi.
(2023)
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response.
iScience
Vitenskapelig artikkel
-
Hermet, Paule;
Delache, Benoît;
Herate, Cecile;
Wolf, Esther;
Kivi, Gaily;
Juronen, Erkki.
(2023)
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates.
PLoS Pathogens
Vitenskapelig artikkel
-
Kamyshnyi, Aleksandr;
Koval, Halyna;
Kobevko, Olha;
Buchynskyi, Mykhailo;
Oksenych, Valentyn;
Kaynov, Denis.
(2023)
Therapeutic Effectiveness of Interferon-α2b against COVID-19 with Community-Acquired Pneumonia: The Ukrainian Experience.
International Journal of Molecular Sciences
Vitenskapelig artikkel
-
Petakh, Pavlo;
Kamyshna, Iryna;
Oksenych, Valentyn;
Kainov, Denis;
Kamyshnyi, Aleksandr.
(2023)
Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment.
Pharmaceuticals
Vitenskapelig artikkel
-
Ravlo, Erlend;
Ianevski, Aleksandr;
Starheim, Eirin Johannessen;
Wang, Wei;
Ji, Ping;
Lysvand, Hilde.
(2023)
Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study.
International Journal of Infectious Diseases
Fagartikkel
-
Benjakul, Sopisa;
Anthi, Aina Karen;
Kolderup, Heidi Anette;
Vaysburd, Marina;
Lode, Heidrun Elisabeth;
Mallery, D.
(2023)
A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery.
PNAS Nexus
Vitenskapelig artikkel
2022
-
Nordbø, Svein Arne;
Linh, Hoang;
Krokstad, Sidsel;
Kainov, Denis;
Sagvik, Eli Oline.
(2022)
Rask eliminasjon av SARS-CoV-2 hos fullvaksinert pasient.
www.tidsskriftet.no
Short communication
-
Oksenych, Valentyn;
Kainov, Denis.
(2022)
Broad-Spectrum Antivirals and Antiviral Drug Combinations.
Viruses
Leder
-
Li, Pengfei;
Li, Yunlong;
Wang, Yijin;
Liu, Jiaye;
Lavrijsen, Marla;
Li, Yang.
(2022)
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids.
Science Advances
Vitenskapelig artikkel
-
Pinto, Sneha M.;
Subbannayya, Yashwanth;
Kim, Hera;
Hagen, Lars;
Górna, Maria W;
Nieminen, Anni I..
(2022)
Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells.
iScience
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Simonsen, Ronja Meyer;
Myhre, Vegard;
Ravlo, Erlend;
Kaynova, Gerda D..
(2022)
Mono- and combinational drug therapies for global viral pandemic preparedness.
iScience
Vitenskapelig oversiktsartikkel/review
-
Ravlo, Erlend;
Evensen, Lasse;
Sanson, Gorm;
Hildonen, Siri;
Ianevski, Aleksandr;
Skjervold, Per Olav.
(2022)
Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 Infection.
Viruses
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Simonsen, Ronja Meyer;
Myhre, Vegard;
Tenson, Tanel;
Oksenych, Valentyn;
Bjørås, Magnar.
(2022)
DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs).
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Kainov, Denis;
Oksenych, Valentyn.
(2022)
Broad-Spectrum Antivirals and Antiviral Combinations: An Editorial Update.
Viruses
Leder
-
Ianevski, Aleksandr;
Zusinaite, Eva;
Tenson, Tanel;
Oksenych, Valentyn;
Wang, Wei;
Afset, Jan Egil.
(2022)
Novel Synergistic Anti-Enteroviral Drug Combinations.
Viruses
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Ahmad, Shahzaib;
Anunnitipat, Kraipit;
Oksenych, Valentyn;
Zusinaite, Eva;
Tenson, Tanel.
(2022)
Seven classes of antiviral agents.
Cellular and Molecular Life Sciences (CMLS)
Vitenskapelig oversiktsartikkel/review
2021
-
Ianevski, Aleksandr;
Yao, Rouan;
Zusinaite, Eva;
Lysvand, Hilde;
Oksenych, Valentyn;
Tenson, Tanel.
(2021)
Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study.
Viruses
Vitenskapelig artikkel
-
Rabben, Hanne-Line;
Andersen, Gøran Troseth;
Olsen, Magnus Kringstad;
Øverby, Anders;
Ianevski, Aleksandr;
Kainov, Denis.
(2021)
Neural signaling modulates metabolism of gastric cancer.
iScience
Vitenskapelig artikkel
-
White, Judith M.;
Schiffer, Joshua T.;
Bender Ignacio, Rachel A.;
Xu, Shuang;
Kainov, Denis;
Ianevski, Aleksandr.
(2021)
Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses.
mBio
Vitenskapelig oversiktsartikkel/review
-
Yao, Rouan;
Ianevski, Aleksandr;
Kainov, Denis.
(2021)
Safe-in-Man Broad Spectrum Antiviral Agents.
Springer
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Li, Yunlong;
Miao, Zhijiang;
Li, Pengfei;
Zhang, Ruyi;
Kainov, Denis;
Ma, Zhongren.
(2021)
Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1.
Archives of Virology
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Zusinaite, Eva;
Lello, Laura Sandra;
Wang, Sainan;
Jo, Eunji.
(2021)
Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections.
Viruses
Vitenskapelig artikkel
-
Kainov, Denis;
Oksenych, Valentyn.
(2021)
DNA Damage Response.
Biomolecules
Leder
-
Meehyun, Ko;
Chang, Soo Young;
Byun, Soo Young;
Ianevski, Aleksandr;
Choi, Inhee;
Pham Hung, Anne-Laure.
(2021)
Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19.
Viruses
Vitenskapelig artikkel
-
Yang, Jaewon;
König, Alexander;
Park, Soonju;
Jo, Eunji;
Sung, Pil Soo;
Yoon, Seung Kew.
(2021)
A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals.
JHEP Reports
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Lysvand, Hilde;
Grødeland, Gunnveig;
Legrand, Nicolas;
Oksenych, Valentyn.
(2021)
Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host tmprss2.
Viruses
Vitenskapelig artikkel
-
Ladner, Jason T.;
Henson, Sierra N.;
Boyle, Annalee S.;
Engelbrektson, Anna L.;
Fink, Zane W.;
Rahee, Fatima.
(2021)
Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses.
Cell Reports Medicine
Vitenskapelig artikkel
-
Rabben, Hanne-Line;
Andersen, Gøran Troseth;
Ianevski, Aleksandr;
Olsen, Magnus Kringstad;
Kainov, Denis;
Grønbech, Jon Erik.
(2021)
Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer.
Frontiers in Pharmacology
Vitenskapelig artikkel
-
Oksenych, Valentyn;
Kainov, Denis.
(2021)
DNA Damage Response.
Biomolecules
Leder
2020
-
Anderssen, Petter Inge;
Ianevski, Aleksandr;
Lysvand, Hilde;
Vitkauskiene, Astra;
Oksenych, Valentyn;
Bjørås, Magnar.
(2020)
Discovery and development of safe-in-man broad-spectrum antiviral agents.
International Journal of Infectious Diseases
Vitenskapelig oversiktsartikkel/review
-
Chen, Sunrui;
Wang, Yining;
Li, Pengfei;
Yin, Yuebang;
Bijvelds, Marcel J.;
de Jonge, Hugo R..
(2020)
Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway.
Antiviral Research
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Fenstad, Mona H.;
Biza, Svetlana;
Zusinaite, Eva;
Reisberg, Tuuli.
(2020)
Potential Antiviral Options against SARS-CoV-2 Infection. Viruses.
Viruses
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Biza, Svetlana;
Zusinaite, Eva;
Mannik, Andres;
Kivi, Gaily.
(2020)
Identification and Tracking of Antiviral Drug Combinations.
Viruses
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Kulesskiy, Evgeny;
Krpina, Klara;
Lou, Guofeng;
Aman, Yahyah;
Bugai, Andrii.
(2020)
Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis.
Cancers
Vitenskapelig artikkel
-
Li, Yunlong;
Li, Pengfei;
Li, Yang;
Zhang, Ruyi;
Yu, Peifa;
Ma, Zhongren.
(2020)
Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation.
Antiviral Research
Vitenskapelig artikkel
2019
-
Ianevski, Aleksandr;
Anderssen, Petter Inge;
Merits, Andres;
Bjørås, Magnar;
Kainov, Denis.
(2019)
Expanding the activity spectrum of antiviral agents.
Drug Discovery Today
Vitenskapelig oversiktsartikkel/review
-
Ianevski, Aleksandr;
Zusinaite, Eva;
Shtaida, Nastassia;
Kallio-Kokko, Hannimari;
Valkonen, Mia;
Kantele, Anu.
(2019)
Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018.
Viruses
Vitenskapelig artikkel
-
Anderssen, Petter Inge;
Krpina, Klara;
Ianevski, Aleksandr;
Shtaida, Nastassia;
Jo, Eunji;
Yang, Jaewon.
(2019)
Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine.
Viruses
Vitenskapelig artikkel
-
Bösl, Korbinian;
Ianevski, Aleksandr;
Than, Thoa T.;
Anderssen, Petter Inge;
Kuivanen, Suvi;
Teppor, Mona.
(2019)
Common nodes of virus-host interaction revealed through an integrated network analysis.
Frontiers in Immunology
Vitenskapelig artikkel
2018
-
Zusinaite, Eva;
Ianevski, Aleksandr;
Niukkanen, Diana;
Poranen, Minna M.;
Bjørås, Magnar;
Afset, Jan Egil.
(2018)
A systems approach to study immuno- and neuro-modulatory properties of antiviral agents.
Viruses
Vitenskapelig oversiktsartikkel/review
-
Loevenich, Simon;
Ianevski, Aleksandr;
Oitmaa, Eneli;
Kainov, Denis;
Anthonsen, Marit Walbye.
(2018)
Single passage of human metapneumovirus in LLCMK2 cells does not affect viral protein-coding capacity.
Microbiology Resource Announcements (MRA)
Short communication
-
Ianevski, Aleksandr;
Zusinaite, Eva;
Kuivanen, Suvi;
Strand, Mårten;
Lysvand, Hilde;
Teppor, Mona.
(2018)
Novel activities of safe-in-human broad-spectrum antiviral agents.
Antiviral Research
Vitenskapelig artikkel
2017
-
Bulanova, Daria;
Ianevski, Aleksandr;
Bugai, Andrii;
Akimov, Yevhen;
Kuivanen, Suvi;
Paavilainen, Henrik.
(2017)
Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins.
Viruses
Vitenskapelig artikkel
-
Gaelings, Lana;
Söderholm, Sandra;
Bugai, Andrii;
Fu, Yu;
Nandania, Jatin;
Schepens, Bert.
(2017)
Regulation of kynurenine biosynthesis during influenza virus infection.
The FEBS Journal
Vitenskapelig artikkel
-
Shim, Jung Min;
Kim, Jinhee;
Tenson, Tanel;
Min, Ji-Young;
Kainov, Denis.
(2017)
Influenza virus infection, interferon response, viral counter-response, and apoptosis.
Viruses
Vitenskapelig oversiktsartikkel/review
2016
-
Nyman, Tuula Anneli;
Söderholm, Sandra;
Kainov, Denis;
Ohman, Tiina;
Denisova, Oxana V.;
Schepens, Bert.
(2016)
Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.
Molecular & Cellular Proteomics
Vitenskapelig artikkel
-
Anastasina, Maria;
Le May, Nicolas;
Bugai, Andrii;
Fu, Yu;
Söderholm, Sandra;
Gaelings, Lana.
(2016)
Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.
Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
Vitenskapelig artikkel
-
Söderholm, Sandra;
Kainov, Denis E.;
Öhman, Tiina;
Denisova, Oxana V.;
Schepens, Bert;
Kulesskiy, Evgeny.
(2016)
Phosphoproteomics to characterize host response during influenza a virus infection of human macrophages.
Molecular & Cellular Proteomics
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Ianevski, Aleksandr;
Frøysa, Irene Trøen;
Lysvand, Hilde;
Calitz, Carlemi;
Smura, Teemu;
Nilsen, Hans-Johnny.
(2024)
The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants.
Antiviral Research
Vitenskapelig artikkel
-
Halabitska, Iryna;
Petakh, Pavlo;
Kamyshna, Iryna;
Oksenych, Valentyn;
Kainov, Denis;
Kamyshnyi, Oleksandr.
(2024)
The interplay of gut microbiota, obesity, and depression: insights and interventions.
Cellular and Molecular Life Sciences (CMLS)
Vitenskapelig oversiktsartikkel/review
-
Wang, Yining;
Li, Pengfei;
Xu, Lei;
de Vries, Annemarie C.;
Rottier, Robbert J.;
Wang, Wenshi.
(2023)
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response.
iScience
Vitenskapelig artikkel
-
Hermet, Paule;
Delache, Benoît;
Herate, Cecile;
Wolf, Esther;
Kivi, Gaily;
Juronen, Erkki.
(2023)
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates.
PLoS Pathogens
Vitenskapelig artikkel
-
Kamyshnyi, Aleksandr;
Koval, Halyna;
Kobevko, Olha;
Buchynskyi, Mykhailo;
Oksenych, Valentyn;
Kaynov, Denis.
(2023)
Therapeutic Effectiveness of Interferon-α2b against COVID-19 with Community-Acquired Pneumonia: The Ukrainian Experience.
International Journal of Molecular Sciences
Vitenskapelig artikkel
-
Petakh, Pavlo;
Kamyshna, Iryna;
Oksenych, Valentyn;
Kainov, Denis;
Kamyshnyi, Aleksandr.
(2023)
Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment.
Pharmaceuticals
Vitenskapelig artikkel
-
Ravlo, Erlend;
Ianevski, Aleksandr;
Starheim, Eirin Johannessen;
Wang, Wei;
Ji, Ping;
Lysvand, Hilde.
(2023)
Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study.
International Journal of Infectious Diseases
Fagartikkel
-
Benjakul, Sopisa;
Anthi, Aina Karen;
Kolderup, Heidi Anette;
Vaysburd, Marina;
Lode, Heidrun Elisabeth;
Mallery, D.
(2023)
A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery.
PNAS Nexus
Vitenskapelig artikkel
-
Nordbø, Svein Arne;
Linh, Hoang;
Krokstad, Sidsel;
Kainov, Denis;
Sagvik, Eli Oline.
(2022)
Rask eliminasjon av SARS-CoV-2 hos fullvaksinert pasient.
www.tidsskriftet.no
Short communication
-
Oksenych, Valentyn;
Kainov, Denis.
(2022)
Broad-Spectrum Antivirals and Antiviral Drug Combinations.
Viruses
Leder
-
Li, Pengfei;
Li, Yunlong;
Wang, Yijin;
Liu, Jiaye;
Lavrijsen, Marla;
Li, Yang.
(2022)
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids.
Science Advances
Vitenskapelig artikkel
-
Pinto, Sneha M.;
Subbannayya, Yashwanth;
Kim, Hera;
Hagen, Lars;
Górna, Maria W;
Nieminen, Anni I..
(2022)
Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells.
iScience
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Simonsen, Ronja Meyer;
Myhre, Vegard;
Ravlo, Erlend;
Kaynova, Gerda D..
(2022)
Mono- and combinational drug therapies for global viral pandemic preparedness.
iScience
Vitenskapelig oversiktsartikkel/review
-
Ravlo, Erlend;
Evensen, Lasse;
Sanson, Gorm;
Hildonen, Siri;
Ianevski, Aleksandr;
Skjervold, Per Olav.
(2022)
Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 Infection.
Viruses
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Simonsen, Ronja Meyer;
Myhre, Vegard;
Tenson, Tanel;
Oksenych, Valentyn;
Bjørås, Magnar.
(2022)
DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs).
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Kainov, Denis;
Oksenych, Valentyn.
(2022)
Broad-Spectrum Antivirals and Antiviral Combinations: An Editorial Update.
Viruses
Leder
-
Ianevski, Aleksandr;
Zusinaite, Eva;
Tenson, Tanel;
Oksenych, Valentyn;
Wang, Wei;
Afset, Jan Egil.
(2022)
Novel Synergistic Anti-Enteroviral Drug Combinations.
Viruses
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Ahmad, Shahzaib;
Anunnitipat, Kraipit;
Oksenych, Valentyn;
Zusinaite, Eva;
Tenson, Tanel.
(2022)
Seven classes of antiviral agents.
Cellular and Molecular Life Sciences (CMLS)
Vitenskapelig oversiktsartikkel/review
-
Ianevski, Aleksandr;
Yao, Rouan;
Zusinaite, Eva;
Lysvand, Hilde;
Oksenych, Valentyn;
Tenson, Tanel.
(2021)
Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study.
Viruses
Vitenskapelig artikkel
-
Rabben, Hanne-Line;
Andersen, Gøran Troseth;
Olsen, Magnus Kringstad;
Øverby, Anders;
Ianevski, Aleksandr;
Kainov, Denis.
(2021)
Neural signaling modulates metabolism of gastric cancer.
iScience
Vitenskapelig artikkel
-
White, Judith M.;
Schiffer, Joshua T.;
Bender Ignacio, Rachel A.;
Xu, Shuang;
Kainov, Denis;
Ianevski, Aleksandr.
(2021)
Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses.
mBio
Vitenskapelig oversiktsartikkel/review
-
Li, Yunlong;
Miao, Zhijiang;
Li, Pengfei;
Zhang, Ruyi;
Kainov, Denis;
Ma, Zhongren.
(2021)
Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1.
Archives of Virology
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Zusinaite, Eva;
Lello, Laura Sandra;
Wang, Sainan;
Jo, Eunji.
(2021)
Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections.
Viruses
Vitenskapelig artikkel
-
Kainov, Denis;
Oksenych, Valentyn.
(2021)
DNA Damage Response.
Biomolecules
Leder
-
Meehyun, Ko;
Chang, Soo Young;
Byun, Soo Young;
Ianevski, Aleksandr;
Choi, Inhee;
Pham Hung, Anne-Laure.
(2021)
Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19.
Viruses
Vitenskapelig artikkel
-
Yang, Jaewon;
König, Alexander;
Park, Soonju;
Jo, Eunji;
Sung, Pil Soo;
Yoon, Seung Kew.
(2021)
A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals.
JHEP Reports
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Lysvand, Hilde;
Grødeland, Gunnveig;
Legrand, Nicolas;
Oksenych, Valentyn.
(2021)
Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host tmprss2.
Viruses
Vitenskapelig artikkel
-
Ladner, Jason T.;
Henson, Sierra N.;
Boyle, Annalee S.;
Engelbrektson, Anna L.;
Fink, Zane W.;
Rahee, Fatima.
(2021)
Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses.
Cell Reports Medicine
Vitenskapelig artikkel
-
Rabben, Hanne-Line;
Andersen, Gøran Troseth;
Ianevski, Aleksandr;
Olsen, Magnus Kringstad;
Kainov, Denis;
Grønbech, Jon Erik.
(2021)
Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer.
Frontiers in Pharmacology
Vitenskapelig artikkel
-
Oksenych, Valentyn;
Kainov, Denis.
(2021)
DNA Damage Response.
Biomolecules
Leder
-
Anderssen, Petter Inge;
Ianevski, Aleksandr;
Lysvand, Hilde;
Vitkauskiene, Astra;
Oksenych, Valentyn;
Bjørås, Magnar.
(2020)
Discovery and development of safe-in-man broad-spectrum antiviral agents.
International Journal of Infectious Diseases
Vitenskapelig oversiktsartikkel/review
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Chen, Sunrui;
Wang, Yining;
Li, Pengfei;
Yin, Yuebang;
Bijvelds, Marcel J.;
de Jonge, Hugo R..
(2020)
Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway.
Antiviral Research
Vitenskapelig artikkel
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Ianevski, Aleksandr;
Yao, Rouan;
Fenstad, Mona H.;
Biza, Svetlana;
Zusinaite, Eva;
Reisberg, Tuuli.
(2020)
Potential Antiviral Options against SARS-CoV-2 Infection. Viruses.
Viruses
Vitenskapelig artikkel
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Ianevski, Aleksandr;
Yao, Rouan;
Biza, Svetlana;
Zusinaite, Eva;
Mannik, Andres;
Kivi, Gaily.
(2020)
Identification and Tracking of Antiviral Drug Combinations.
Viruses
Vitenskapelig artikkel
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Ianevski, Aleksandr;
Kulesskiy, Evgeny;
Krpina, Klara;
Lou, Guofeng;
Aman, Yahyah;
Bugai, Andrii.
(2020)
Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis.
Cancers
Vitenskapelig artikkel
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Li, Yunlong;
Li, Pengfei;
Li, Yang;
Zhang, Ruyi;
Yu, Peifa;
Ma, Zhongren.
(2020)
Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation.
Antiviral Research
Vitenskapelig artikkel
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Ianevski, Aleksandr;
Anderssen, Petter Inge;
Merits, Andres;
Bjørås, Magnar;
Kainov, Denis.
(2019)
Expanding the activity spectrum of antiviral agents.
Drug Discovery Today
Vitenskapelig oversiktsartikkel/review
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Ianevski, Aleksandr;
Zusinaite, Eva;
Shtaida, Nastassia;
Kallio-Kokko, Hannimari;
Valkonen, Mia;
Kantele, Anu.
(2019)
Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018.
Viruses
Vitenskapelig artikkel
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Anderssen, Petter Inge;
Krpina, Klara;
Ianevski, Aleksandr;
Shtaida, Nastassia;
Jo, Eunji;
Yang, Jaewon.
(2019)
Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine.
Viruses
Vitenskapelig artikkel
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Bösl, Korbinian;
Ianevski, Aleksandr;
Than, Thoa T.;
Anderssen, Petter Inge;
Kuivanen, Suvi;
Teppor, Mona.
(2019)
Common nodes of virus-host interaction revealed through an integrated network analysis.
Frontiers in Immunology
Vitenskapelig artikkel
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Zusinaite, Eva;
Ianevski, Aleksandr;
Niukkanen, Diana;
Poranen, Minna M.;
Bjørås, Magnar;
Afset, Jan Egil.
(2018)
A systems approach to study immuno- and neuro-modulatory properties of antiviral agents.
Viruses
Vitenskapelig oversiktsartikkel/review
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Loevenich, Simon;
Ianevski, Aleksandr;
Oitmaa, Eneli;
Kainov, Denis;
Anthonsen, Marit Walbye.
(2018)
Single passage of human metapneumovirus in LLCMK2 cells does not affect viral protein-coding capacity.
Microbiology Resource Announcements (MRA)
Short communication
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Ianevski, Aleksandr;
Zusinaite, Eva;
Kuivanen, Suvi;
Strand, Mårten;
Lysvand, Hilde;
Teppor, Mona.
(2018)
Novel activities of safe-in-human broad-spectrum antiviral agents.
Antiviral Research
Vitenskapelig artikkel
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Bulanova, Daria;
Ianevski, Aleksandr;
Bugai, Andrii;
Akimov, Yevhen;
Kuivanen, Suvi;
Paavilainen, Henrik.
(2017)
Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins.
Viruses
Vitenskapelig artikkel
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Gaelings, Lana;
Söderholm, Sandra;
Bugai, Andrii;
Fu, Yu;
Nandania, Jatin;
Schepens, Bert.
(2017)
Regulation of kynurenine biosynthesis during influenza virus infection.
The FEBS Journal
Vitenskapelig artikkel
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Shim, Jung Min;
Kim, Jinhee;
Tenson, Tanel;
Min, Ji-Young;
Kainov, Denis.
(2017)
Influenza virus infection, interferon response, viral counter-response, and apoptosis.
Viruses
Vitenskapelig oversiktsartikkel/review
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Nyman, Tuula Anneli;
Söderholm, Sandra;
Kainov, Denis;
Ohman, Tiina;
Denisova, Oxana V.;
Schepens, Bert.
(2016)
Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.
Molecular & Cellular Proteomics
Vitenskapelig artikkel
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Anastasina, Maria;
Le May, Nicolas;
Bugai, Andrii;
Fu, Yu;
Söderholm, Sandra;
Gaelings, Lana.
(2016)
Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.
Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
Vitenskapelig artikkel
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Söderholm, Sandra;
Kainov, Denis E.;
Öhman, Tiina;
Denisova, Oxana V.;
Schepens, Bert;
Kulesskiy, Evgeny.
(2016)
Phosphoproteomics to characterize host response during influenza a virus infection of human macrophages.
Molecular & Cellular Proteomics
Vitenskapelig artikkel
Del av bok/rapport
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Yao, Rouan;
Ianevski, Aleksandr;
Kainov, Denis.
(2021)
Safe-in-Man Broad Spectrum Antiviral Agents.
Springer
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
Undervisning
Emner
Formidling
The enormous but unknown curative power of old drugs
A legislative reform being prepared by the European Union plans to promote the use of already approved drugs to treat other illnesses. Doing so will speed up the approval of treatments and save on research costs
Why you should be vaccinated even if you have had COVID-19
Convalescent plasma therapy research provides an unanticipated insight into how the body fights COVID-19 variants
Rapid passive immunity via inhalation - a novel approach against respiratory pathogens
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates
A long-acting biologic with transmucosal transport properties that arrest SARS-CoV-2 virus variants
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