Barbara van Loon
Barbara van Loon
Professor, Nestleder Clinical Academic Group (CAG) - Sjeldne Genetiske Sykdommer
barbara.v.loon@ntnu.no
Om
Barbara van Loon tok doktorgrad med utmerkelse (Magna cum Laude) ved Universitetet i Zürich (UZH, Sveits) i 2009. Hun fortsatte sin forskerkarriere som postdoktor ved Massachusetts Institute of Technology (Cambridge, USA). I 2011 startet hun som uavhengig gruppeleder ved Institutt for molekylære mekanismer ved sykdommer, UZH (Sveits). Hun ble tildelt Onsager Fellowship ved NTNU i 2016, og begynte som førsteamanuensis på NTNU. Barbara var videre en del av Outstanding Academic Fellows Program ved NTNU (2017-2021). Hun ble professor i 2020.
Forskningen til Barbara van Loon fokuserer på å bestemme virkningen av genom- og epigenomdynamikk på essensielle cellulære prosesser som er relevante for fysiologisk og patologisk utvikling. For hennes studier av den cellulære responsen på DNA-skade og betydningen dette har for kreft og utviklingsforstyrrelser i nervesystemet, ble Barbara i 2021 tildelt Anders Jahre medisinske pris til yngre forskere. Siden 2022 har Barbara vært medleder av Clinical Academic Group (CAG) for sjeldne genetiske sykdommer. CAG er en organisasjon støttet av Samarbeidsorganet i Helse Midt-Norge som koordinerer forskningsaktiviteter på tvers av tre helseforetak og ved NTNU, med hovedmål å fremme klinikken gjennom fremskritt innen forskning.
Forskning
Research group: "Genome dynamics during physiological and disease development"
Our research
Numerous lethal and mutagenic DNA lesions are formed upon exposure to endogenous and exogenous damaging agents. The estimated steady-state level of endogenous DNA damage in mammalian cells is high, about 20’000 lesions per cell per day. Aberrant DNA bases represent significant portion of endogenous DNA damage. To maintain the integrity of genetic information organized within chromatin, cells need to efficiently repair the DNA. Accumulation of aberrant DNA bases has been tightly associated with aging, cancer development, as well as the onset of different neurological diseases. Aim of our research is to determine how presence of aberrant DNA bases influences essential cellular processes, like transcription and gene expression, as well as to identify different factors that ensure efficient repair. By using multidisciplinary approaches (including biochemistry, cell biology, genomics, proteomics, 3D culturing, imaging, CRISPR libraries, and computational biology) we focus on identification of pathomechanisms that lead to development of human diseases, in particular neurodevelopmental disorders and cancer, and which could potentially serve as basis for evolution of novel therapies.
Group members
- Merdane E. Aksu (https://www.ntnu.no/ansatte/merdane.e.aksu)
- Rabina Dumaru (https://www.ntnu.no/ansatte/rabina.dumaru)
- Kayla M. Grooms (https://www.ntnu.edu/employees/kaylag)
- Marte Gjøl Haug (https://www.ntnu.no/ansatte/marte.g.haug)
- Kristin Rian (https://www.ntnu.no/ansatte/kristin.rian)
Master students:
- Martine Engebakken Berg
Publikasjoner
2024
-
Bordin, Diana Lilian;
Grooms, Kayla Mae;
Montaldo, Nicola Pietro;
Fordyce Martin, Sarah Louise;
Sætrom, Pål;
Samson, Leona D..
(2024)
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory.
DNA Repair
Vitenskapelig artikkel
-
Glærum, Ingvild Lynneberg;
Dunville, Keagan;
Moan, Kristian Magnus;
Krause, Maike;
Montaldo, Nicola Pietro;
Kirikae, Hinaco.
(2024)
Postnatal persistence of hippocampal Cajal-Retzius cells has a critical role in the establishment of the hippocampal circuit.
Development
Vitenskapelig artikkel
-
Shimada, Kenji;
Tarashev, Cleo V. D.;
Bregenhorn, Stephanie;
Gerhold, Christian B.;
van Loon, Barbara;
Roth, Gregory.
(2024)
TORC2 inhibition triggers yeast chromosome fragmentation through misregulated Base Excision Repair of clustered oxidation events.
Nature Communications
Vitenskapelig artikkel
2023
-
Andersson-Rusch, Clara Leticia;
Quist-Løkken, Ingrid;
Sætrom, Pål;
Beisvag, Vidar;
Rolinski, Milosz;
Aas, Per Arne.
(2023)
Genome-Wide CRISPR/Cas9 Knock-out Screen Identifies Apoptosis-Relevant Genes in Multiple Myeloma.
Blood
Sammendrag/abstract
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Vitenskapelig artikkel
-
Loevenich, Simon;
Montaldo, Nicola Pietro;
Wickenhagen, Arthur;
Sherstova, Tatyana;
van Loon, Barbara;
Boyartchuk, Victor.
(2023)
Human metapneumovirus driven IFN-β production antagonizes macrophage transcriptional induction of IL1-β in response to bacterial pathogens.
Frontiers in Immunology
Vitenskapelig artikkel
2022
-
Bittner-Schwerda, L.;
Malama, E.;
Siuda, M.;
van Loon, Barbara;
Bollwein, H..
(2022)
The sperm chromatin structure assay does not detect alterations in sperm chromatin structure induced by hydrogen peroxide.
Animal Reproduction Science
Vitenskapelig artikkel
-
Jang, Sunbok;
Kumar, Namrata;
Schaich, Mathew A.;
Zhong, Zhou;
van Loon, Barbara;
Watkins, Simon C..
(2022)
Cooperative interaction between AAG and UV-DDB in the removal of modified bases.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2021
-
Aprigliano, Rossana;
Aksu, Merdane Ezgi;
Bradamante, Stefano;
Mihaljevic, Boris;
Wang, Wei;
Rian, Kristin.
(2021)
Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities.
Cell Reports Medicine
Vitenskapelig artikkel
-
Rolinski, Milosz;
Montaldo, Nicola Pietro;
Aksu, Merdane Ezgi;
Martin, Sarah Fordyce;
Brambilla, Alessandro;
Kunath, Nicolas.
(2021)
Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2019
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications
Vitenskapelig artikkel
2018
-
Valla, Marit;
Mjønes, Patricia;
Engstrøm, Monica J;
Ytterhus, Borgny;
Bordin, Diana Lilian;
van Loon, Barbara.
(2018)
Characterization of FGD5 expression in primary breast cancers and lymph node metastases.
Journal of Histochemistry and Cytochemistry
Vitenskapelig artikkel
-
Bittner, Lilli;
Wyck, Sarah;
Herrera, Carolina;
Siuda, M;
Wrenzycki, Christine;
van Loon, Barbara.
(2018)
Negative effects of oxidative stress in bovine spermatozoa on in vitro development and DNA integrity of embryos.
Reproduction, Fertility and Development
Vitenskapelig artikkel
-
Bosshard, Matthias;
Aprigliano, Rossana;
Gattiker, Cristina;
Palibrk, Vuk;
Markkanen, Enni;
Backe, Paul Hoff.
(2018)
Publisher Correction: Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.
Scientific Reports
Errata
2017
-
Moortgat, Stéphanie;
Berland, Siren;
Aukrust, Ingvild;
Maystadt, Isabelle;
Baker, Laura;
Benoit, Valerie.
(2017)
HUWE1 variants cause dominant X-linked intellectual disability: a clinical study of 21 patients.
European Journal of Human Genetics
Vitenskapelig artikkel
-
Mentegari, Elisa;
Crespan, Emmanuele;
Bavagnoli, Laura;
Kissova, Miroslava;
Bertoletti, Federica;
Sabbioneda, Simone.
(2017)
Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Bosshard, Matthias;
Aprigliano, Rossana;
Gattiker, Cristina;
Palibrk, Vuk;
Markkanen, Enni;
Backe, Paul Hoff.
(2017)
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.
Scientific Reports
Vitenskapelig artikkel
-
van Loon, Barbara;
Hübscher, Ulrich;
Maga, Giovanni.
(2017)
Living on the edge: DNA polymerase lambda between genome stability and mutagenesis.
Chemical Research in Toxicology
Vitenskapelig oversiktsartikkel/review
-
Martin-Pardillos, Ana;
Tsaalbi-Shtylik, Anastasia;
Chen, Si;
Lazare, Seka;
Van Os, Ronald P;
Dethmers-Ausema, Albertina.
(2017)
Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.
Blood
Vitenskapelig artikkel
2016
-
Räz, Michael H;
Dexter, Hannah R;
Millington, Christopher L;
van Loon, Barbara;
Williams, David M;
Sturla, Shana J.
(2016)
Bypass of Mutagenic O6-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases.
Chemical Research in Toxicology
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Bordin, Diana Lilian;
Grooms, Kayla Mae;
Montaldo, Nicola Pietro;
Fordyce Martin, Sarah Louise;
Sætrom, Pål;
Samson, Leona D..
(2024)
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory.
DNA Repair
Vitenskapelig artikkel
-
Glærum, Ingvild Lynneberg;
Dunville, Keagan;
Moan, Kristian Magnus;
Krause, Maike;
Montaldo, Nicola Pietro;
Kirikae, Hinaco.
(2024)
Postnatal persistence of hippocampal Cajal-Retzius cells has a critical role in the establishment of the hippocampal circuit.
Development
Vitenskapelig artikkel
-
Shimada, Kenji;
Tarashev, Cleo V. D.;
Bregenhorn, Stephanie;
Gerhold, Christian B.;
van Loon, Barbara;
Roth, Gregory.
(2024)
TORC2 inhibition triggers yeast chromosome fragmentation through misregulated Base Excision Repair of clustered oxidation events.
Nature Communications
Vitenskapelig artikkel
-
Andersson-Rusch, Clara Leticia;
Quist-Løkken, Ingrid;
Sætrom, Pål;
Beisvag, Vidar;
Rolinski, Milosz;
Aas, Per Arne.
(2023)
Genome-Wide CRISPR/Cas9 Knock-out Screen Identifies Apoptosis-Relevant Genes in Multiple Myeloma.
Blood
Sammendrag/abstract
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Vitenskapelig artikkel
-
Loevenich, Simon;
Montaldo, Nicola Pietro;
Wickenhagen, Arthur;
Sherstova, Tatyana;
van Loon, Barbara;
Boyartchuk, Victor.
(2023)
Human metapneumovirus driven IFN-β production antagonizes macrophage transcriptional induction of IL1-β in response to bacterial pathogens.
Frontiers in Immunology
Vitenskapelig artikkel
-
Bittner-Schwerda, L.;
Malama, E.;
Siuda, M.;
van Loon, Barbara;
Bollwein, H..
(2022)
The sperm chromatin structure assay does not detect alterations in sperm chromatin structure induced by hydrogen peroxide.
Animal Reproduction Science
Vitenskapelig artikkel
-
Jang, Sunbok;
Kumar, Namrata;
Schaich, Mathew A.;
Zhong, Zhou;
van Loon, Barbara;
Watkins, Simon C..
(2022)
Cooperative interaction between AAG and UV-DDB in the removal of modified bases.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Aprigliano, Rossana;
Aksu, Merdane Ezgi;
Bradamante, Stefano;
Mihaljevic, Boris;
Wang, Wei;
Rian, Kristin.
(2021)
Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities.
Cell Reports Medicine
Vitenskapelig artikkel
-
Rolinski, Milosz;
Montaldo, Nicola Pietro;
Aksu, Merdane Ezgi;
Martin, Sarah Fordyce;
Brambilla, Alessandro;
Kunath, Nicolas.
(2021)
Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications
Vitenskapelig artikkel
-
Valla, Marit;
Mjønes, Patricia;
Engstrøm, Monica J;
Ytterhus, Borgny;
Bordin, Diana Lilian;
van Loon, Barbara.
(2018)
Characterization of FGD5 expression in primary breast cancers and lymph node metastases.
Journal of Histochemistry and Cytochemistry
Vitenskapelig artikkel
-
Bittner, Lilli;
Wyck, Sarah;
Herrera, Carolina;
Siuda, M;
Wrenzycki, Christine;
van Loon, Barbara.
(2018)
Negative effects of oxidative stress in bovine spermatozoa on in vitro development and DNA integrity of embryos.
Reproduction, Fertility and Development
Vitenskapelig artikkel
-
Bosshard, Matthias;
Aprigliano, Rossana;
Gattiker, Cristina;
Palibrk, Vuk;
Markkanen, Enni;
Backe, Paul Hoff.
(2018)
Publisher Correction: Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.
Scientific Reports
Errata
-
Moortgat, Stéphanie;
Berland, Siren;
Aukrust, Ingvild;
Maystadt, Isabelle;
Baker, Laura;
Benoit, Valerie.
(2017)
HUWE1 variants cause dominant X-linked intellectual disability: a clinical study of 21 patients.
European Journal of Human Genetics
Vitenskapelig artikkel
-
Mentegari, Elisa;
Crespan, Emmanuele;
Bavagnoli, Laura;
Kissova, Miroslava;
Bertoletti, Federica;
Sabbioneda, Simone.
(2017)
Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Bosshard, Matthias;
Aprigliano, Rossana;
Gattiker, Cristina;
Palibrk, Vuk;
Markkanen, Enni;
Backe, Paul Hoff.
(2017)
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.
Scientific Reports
Vitenskapelig artikkel
-
van Loon, Barbara;
Hübscher, Ulrich;
Maga, Giovanni.
(2017)
Living on the edge: DNA polymerase lambda between genome stability and mutagenesis.
Chemical Research in Toxicology
Vitenskapelig oversiktsartikkel/review
-
Martin-Pardillos, Ana;
Tsaalbi-Shtylik, Anastasia;
Chen, Si;
Lazare, Seka;
Van Os, Ronald P;
Dethmers-Ausema, Albertina.
(2017)
Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.
Blood
Vitenskapelig artikkel
-
Räz, Michael H;
Dexter, Hannah R;
Millington, Christopher L;
van Loon, Barbara;
Williams, David M;
Sturla, Shana J.
(2016)
Bypass of Mutagenic O6-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases.
Chemical Research in Toxicology
Vitenskapelig artikkel
Undervisning
Emner
- MOL3000 - Introduction to Molecular Medicine
- MOL3100 - Introduction to Molecular Medicine with Project
Veiledning
Currently supervising one Master Students and three PhD students, two as main supervisor and one as a co-supervisor.
Formidling
Norsk klinisk-akademisk gruppe vil øke kompetansen på metakromatisk leukodystrofi
Helse Midt-Norge har opprettet en klinisk-akademisk gruppe for å øke kompetansen på diagnostisering, oppfølging og behandling av sjeldne, genetiske sykdommer. Gruppen skal blant annet se nærmere på metakromatisk leukodystrofi (MLD).
Keeping DNA healthy
DNA contains information of life and is an essential biomolecule in each cell of our body. To stay healthy, it is crucial to preserve DNA information. In this TEDx talk I discusses how we can contribute to keeping healthy our DNA and with it ourselves.
Dyrket minihjerner og fant nøkkelen til uvanlige syndrom
NTNU-forsker fant at flere sjeldne diagnoser har en felles årsak. «Skurken» er også kjent for å forårsake kreft.
Mini-brains reveal cause of rare syndromes
The culprit behind a large number of cancerous tumours is known to be a certain protein. Now for the first time, research shows that the same protein is the cause of several rare brain syndromes.
Fant samtalen som finner sted i menneskets DNA
Et nytt funn om hvordan celler reparerer seg selv, kan ha betydning for hvordan fremtidens kreftmedisiner skal lages.
Cross-talk between enzymes that read and correct recipes in the cookbook of life
Even the best chef can make mistakes – even when using the recipes (genes) from the “cookbook of life” — DNA. A new discovery as to how cells repair their DNA may have implications for the future drug development.
Skrur av gener for å finne bedre kreftbehandling
Hvilke celler dør og hvilke overlever når de blir behandlet med en spesiell type cellegift? Svaret kan gi kreftsyke en mer effektiv behandling med færre bivirkninger.
Turning genes off for better cancer treatment
Towards new cancer treatments.
2023
-
PosterAndersson-Rusch, Clara Leticia; Quist-Løkken, Ingrid; Sætrom, Pål; Beisvag, Vidar; Rolinski, Milosz; Møen, Johanna. (2023) Genome-Wide CRISPR/Cas9 Knock-out Screen Identifies Apoptosis-Relevant Genes in Multiple Myeloma. American Society of Hematology 65th ASH Annual Meeting and Exposition 2023-12-09 - 2023-12-12
2019
-
PosterAnthonsen, Marit Walbye; Boyartchuk, Victor; Loevenich, Simon; van Loon, Barbara; Montaldo, Nicola Pietro; Sherstova, Tatyana. (2019) Human metapneumovirus impairs antibacterial transcription by introducing H3K27 trimethylation at the IL1B promoter. CEMIR/NTNU Conference on Molecular Mechanisms of Inflammation , Trondheim 2019-06-03 - 2019-06-06